Type 2 diabetes mitigation in the diabetic Goto-Kakizaki rat by elevated bile acids following a common-bile-duct surgery

Metabolism: Clinical and Experimental
Feng GaoXiao Han

Abstract

Elevated plasma bile acids after bariatric surgery are thought to explain type 2 diabetes mellitus (T2DM) remission. Bile acids can bind to and activate the nuclear receptor farnesoid-X receptor (FXR) by regulating lipid and glucose metabolism. We performed a surgical procedure (ligation of the common bile duct and external biliary drainage [LBD]) in the diabetic Goto-Kakizaki (GK) rat in order to investigate its effect on bile acids metabolism and T2DM mitigation. LBD surgery and sham control surgery were performed on diabetic GK rats. The concentrations of total bile acids and blood glucose were analyzed by an automatic analyzer. Intraperitoneal glucose tolerance test (IPGTT) and insulin tolerance test (ITT) were used to monitor blood glucose level. Expression of genes involved in bile acid metabolism (FXR, CYP7A, et al.) and glycolipid metabolism (G6Pase, PEPCK, et al) was analyzed using qRT-PCR. The protein levels of pAKT, AKT and pGSK3β were tested by western blot. The morphological alterations of the liver and epididymal fat were monitored by H&E staining. LBD increased plasma total bile acids, improved hepatic insulin sensitivity, and eventually mitigated T2DM, whereas food intake and body weight were unaltered. Post-LBD...Continue Reading

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Citations

Nov 12, 2016·Metabolism: Clinical and Experimental·Wan-Ni ZhaoJin-Ning Lou
Nov 15, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C BlanchardC Le May
Jul 30, 2016·Endocrinology and Metabolism·Anna Gavrieli, Christos S Mantzoros
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A FiggeL P Bechmann

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