Type 2 diabetic patients with Graves' disease have more frequent and severe Graves' orbitopathy

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
R Le MoliR Vigneri

Abstract

Due to the worldwide increasing prevalence of diabetes (DM), patients with both diabetes and Graves' disease (GD) have become more frequent. Sporadic reports indicate that Graves' orbitopathy (GO), a GD complication that affects orbital soft tissues, can be severe in DM patients. The relationship between these diseases is not well understood. This study aims at evaluating the association of GD and GO with autoimmune and non-autoimmune diabetes (DM) and to assess diabetic features that influence GD and GO prevalence and severity. This retrospective study evaluated GD, GO and DM association in 1211 consecutive GD patients (447 with GO and 77 with DM). A case-control study was carried out to evaluate DM relationship with GO severity by comparing at 1:2 ratio GO patients with or without DM. A strong association was found between GD and T1DM (p = 0.01) but not T2DM. Instead, the presence of GO was strongly associated with T2DM (p = 0.01). Moreover, GO was more frequently severe in GD patients with T2DM (11/30 or 36.6%) than in those without T2DM (1/60 or 1.7%, p = 0.05). T2DM was the strongest risk factor for severe GO (OR = 34.1 vs. 4.4 p < 0.049 in cigarette smokers). DM duration, obesity and vascular complications, but not metabo...Continue Reading

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Citations

Nov 11, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M LaclaustraJ A Casasnovas
Oct 5, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sanjay KalraDeepak Khandelwal
Nov 8, 2020·European Journal of Ophthalmology·Ofira ZlotoGuy Ben Simon
Oct 17, 2020·Ophthalmic Plastic and Reconstructive Surgery·Suryasnata RathMohammad Hasnat Ali

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