Type and doses of oral anticoagulants and adherence to anticoagulant treatment in elderly patients with atrial fibrillation: the ESPARTA study

Journal of Comparative Effectiveness Research
Jose María MostazaCarles Ràfols

Abstract

To analyze the use of oral anticoagulants in elderly patients with atrial fibrillation in clinical practice. Cross-sectional and multicenter study performed in atrial fibrillation patients ≥75 years treated with oral anticoagulants ≥3 months. 837 patients (83.0 ± 5.0 years; CHA2DS2-VASc 5.0 ± 1.4; HAS-BLED 2.1 ± 0.9; 70.8% vitamin K antagonists; 29.2% direct oral anticoagulants [DOACs]) were included. Poor adherence was observed in 27.9% of patients. Higher scores in the Pfeiffer's test and FRAIL scale were associated with poorer adherence. Among patients treated with DOACs, 62.3% received the lower doses. Having high CHADS2 score and being older were associated with the use of low doses. 28% of patients had a poor adherence to anticoagulant treatment. 62% of patients were treated with the lower doses of DOACs.

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Citations

Mar 27, 2019·Current Medical Research and Opinion·Cesar Caro MartinezSergio Manzano Fernández
Aug 31, 2019·Future Cardiology·Olga Gavín SebastiánLuis Palomera Bernal

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