Type F scavenger receptor SREC-I interacts with advillin, a member of the gelsolin/villin family, and induces neurite-like outgrowth.

The Journal of Biological Chemistry
Mami ShibataHiroyuki Arai

Abstract

The scavenger receptor expressed by endothelial cells (SREC) was isolated from a human endothelial cell line and consists of two isoforms named SREC-I and -II. Both isoforms have no significant homology to other types of scavenger receptors. They contain 10 repeats of epidermal growth factor-like cysteine-rich motifs in the extracellular domains and have unusually long C-terminal cytoplasmic domains with Ser/Pro-rich regions. The extracellular domain of SREC-I binds modified low density lipoprotein and mediates a homophilic SREC-I/SREC-I or heterophilic SREC-I/SREC-II trans-interaction. However, the significance of large Ser/Pro-rich cytoplasmic domains of SRECs is not clear. Here, we found that when SREC-I was overexpressed in murine fibroblastic L cells, neurite-like outgrowth was induced, indicating that the receptor can lead to changes in cell morphology. The SREC-I-mediated morphological change required the cytoplasmic domain of the protein, and we identified advillin, a member of the gelsolin/villin family of actin regulatory proteins, as a protein binding to this domain. Reduction of advillin expression in L cells by RNAi led to the absence of the described SREC-I-induced morphological changes, indicating that advillin i...Continue Reading

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J L GoldsteinM S Brown
Sep 8, 1995·The Journal of Biological Chemistry·A N Akopian, J N Wood
Feb 12, 1998·The Journal of Biological Chemistry·H AdachiK Inoue
Nov 24, 1999·The Journal of Cell Biology·W B KiossesM A Schwartz
Feb 19, 2002·The European Journal of Neuroscience·Samantha J RavenallArmen N Akopian
Jun 22, 2002·The Journal of Biological Chemistry·Hideki Adachi, Masafumi Tsujimoto
Jul 12, 2002·Nature·Gregory J Hannon
Feb 5, 2003·Biochemical and Biophysical Research Communications·Setsuko Mise-OmataOreste Acuto
Feb 7, 2003·Current Medicinal Chemistry·Michaela ScherrMatthias Eder

❮ Previous
Next ❯

Citations

May 21, 2005·Atherosclerosis·Jane E MurphySreenivasan Ponnambalam
Aug 10, 2013·Nature Reviews. Immunology·Johnathan CantonSergio Grinstein
Dec 22, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Brent M BanyKirsten S Eckstrum
Sep 6, 2005·Molecular and Cellular Neurosciences·Nathalie VerpoortenVincent Timmerman
Sep 13, 2011·Molecular Pain·Sandra ZurborgPaul A Heppenstall
Jun 26, 2007·Biochemical and Biophysical Research Communications·Junko IshiiMasafumi Tsujimoto
Jun 12, 2013·Cytoskeleton·Shalini NagLeslie D Burtnick
Feb 20, 2010·PloS One·Ethan CeramiChris Sander
Oct 28, 2017·Molecular Biology of the Cell·Sunandini ChandraDebi P Sarkar
May 10, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mercy R PrabhuDasJoseph El Khoury
Dec 30, 2006·The Journal of Biological Chemistry·Tomasa BarrientosNorbert Frey
Feb 25, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mercy PrabhudasJoseph El Khoury
Aug 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jia PengMartin M Matzuk
Aug 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yu-Chia ChuangChih-Cheng Chen
Jun 3, 2020·Scientific Reports·Amin EsmaeilniakooshkghaziSeema Khurana

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.