Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes

Biology of Reproduction
E GomezB Jégou

Abstract

Despite clear indications of interleukin-1 (IL-1) action on Sertoli and germ cells, previous studies failed to detect IL-1 receptors (IL-1R) within the seminiferous tubules. Here, we investigated the existence of the type I signaling receptor (IL-1RI) and the type II decoy receptor (IL-1RII) mRNAs within the testis. Polymerase chain reaction analysis showed the presence of both receptor mRNAs in isolated rat, mouse, and human somatic testicular cells (macrophages, Leydig, Sertoli, and peritubular cells). While also present in rat and mouse isolated pachytene spermatocytes and early spermatids, these receptor mRNAs were not found in human germ cells. The distribution of both IL-1R mRNAs was then examined in adult rat and mouse testis using light and electron microscopic in situ hybridization. No IL-1RI signal was detected in rat testis. In mouse testis, we did not find any signal for IL-1RII. In contrast, IL-1RI mRNA was detected in a wide variety of mouse testicular cells. Strong expression was observed in the rete testis area and high expression was seen over the epithelium of the epididymal duct and in interstitial cells, while lower labeling was detected in peritubular and Sertoli cells and in all germ cell types from sperma...Continue Reading

Citations

Jul 12, 2011·Cellular and Molecular Life Sciences : CMLS·Pearl P Y LieDolores D Mruk
Mar 1, 2003·Journal of Reproductive Immunology·Mark P Hedger, Andreas Meinhardt
May 4, 2002·Molecular and Cellular Endocrinology·Mahmoud Huleihel, Eitan Lunenfeld
Mar 20, 2002·American Journal of Reproductive Immunology : AJRI·Mahmoud HuleihelMoshe Mazor
Jan 18, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mahmoud Abu ElheijaMahmoud Huleihel
May 17, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·María Fernanda RieraSelva Beatriz Cigorraga
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Jan 26, 2006·American Journal of Reproductive Immunology : AJRI·Mahmoud Abu ElhijaMahmoud Huleihel
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