Type I cytokine profiles of human naïve and memory B lymphocytes: a potential for memory cells to impact polarization.

Immunology
Alenka GagroJohn Gordon

Abstract

B cells bifurcating along 'type 1' or 'type 2' pathways under the influence of polarizing cytokines can, in turn, influence the direction of an immune response. Here, we compare the capacity of human B cells residing within naïve and memory compartments to participate in type 1 polarizing responses. B-cell receptor (BCR) engagement provided the main signal for interleukin (IL)-12Rbeta1 expression in the two subsets: this was potentiated by CD154 together with interferon-gamma (IFN-gamma) but inhibited by IL-12. IL-12Rbeta2 could be induced on a minority of B cells by the same signals, and also by IFN-gamma alone. WSX-1, a receptor for IL-27, was expressed in both subsets with no evidence for its regulation by the signals studied. While neither subset was capable of secreting much IL-12 p70, memory B cells could produce a small amount of IL-12 p40 on CD40 ligation. Memory B cells also, exclusively, expressed IL-23 p19 mRNA on BCR triggering. Importantly, products of appropriately stimulated memory--but not naive--B cells were shown to promote the synthesis of IFN-gamma in uncommitted T-helper cells. The data indicate an equal capacity for naïve and memory B cells to respond within a type 1 polarizing environment. Although poorly...Continue Reading

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Citations

Jun 17, 2009·The Journal of Infectious Diseases·Krishanthi SubramaniamLiise-Anne Pirofski
Apr 18, 2008·Current Opinion in Immunology·Frances E Lund
Jun 26, 2008·Arthritis and Rheumatism·Christophe JaminPierre Youinou
Sep 12, 2012·European Journal of Immunology·Darawan RinchaiGanjana Lertmemongkolchai
Apr 3, 2012·Scientific Reports·Alicia D HennMartin S Zand
Mar 11, 2016·Clinical & Translational Immunology·Justine R SmithBinoy Appukuttan
Mar 3, 2017·Immunity, Inflammation and Disease·Ilana C van RensburgAndre G Loxton
Dec 25, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emily R PiersonJoan M Goverman
Jun 26, 2021·Frontiers in Immunology·Rick WilbrinkGwenny M Verstappen

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