Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Matthew J JohnsonRichard A Koup

Abstract

Recombinant adenovirus (rAd) vectors are being investigated as vaccine delivery vehicles in preclinical and clinical studies. rAds constructed from different serotypes differ in receptor usage, tropism, and ability to activate cells, aspects of which likely contribute to their different immunogenicity profiles. In this study, we compared the infectivity and cell stimulatory capacity of recombinant adenovirus serotype 5 (rAd5), recombinant adenovirus serotype 28 (rAd28), and recombinant adenovirus serotype 35 (rAd35) in association with their respective immunogenicity profiles. We found that rAd28 and rAd35 infected and led to the in vitro maturation and activation of both human and mouse dendritic cells more efficiently compared with rAd5. In stark contrast to rAd5, rAd28 and rAd35 induced production of IFN-α and stimulated IFN-related intracellular pathways. However, the in vivo immunogenicity of rAd28 and rAd35 was significantly lower than that of rAd5. Deletion of IFN-α signaling during vaccination with rAd28 and rAd35 vectors increased the magnitude of the insert-specific T cell response to levels induced by vaccination with rAd5 vector. The negative impact of IFN-α signaling on the magnitude of the T cell response could be...Continue Reading

References

Jan 7, 1998·Journal of Virology·J M BergelsonR W Finberg
Feb 2, 1999·The Journal of Experimental Medicine·P MarrackT Mitchell
Feb 2, 1999·The Journal of Experimental Medicine·R Maldonado-LópezM Moser
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B PulendranC R Maliszewski
Nov 24, 1999·Immunological Reviews·D F ToughJ Sprent
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A DzionekJ Schmitz
Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Jan 18, 2003·Science·Chandrashekhar Pasare, Ruslan Medzhitov
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kenya HondaTadatsugu Taniguchi
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Jun 22, 2005·The Journal of Experimental Medicine·Karin LoréRichard A Koup
Sep 1, 2005·The Journal of Experimental Medicine·Ganesh A KolumamKaja Murali-Krishna
Sep 15, 2005·Journal of Virology·Yuanming Zhang, Jeffrey M Bergelson
Nov 17, 2005·The Journal of Experimental Medicine·David A PriceDaniel C Douek
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
May 13, 2006·Science·Adolfo García-Sastre, Christine A Biron
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucas J ThompsonKaja Murali-Krishna
Sep 16, 2006·Human Gene Therapy·Manel CascalloRamon Alemany
Sep 19, 2006·Immunity·Daniel B Stetson, Ruslan Medzhitov
Oct 6, 2006·Journal of Clinical Microbiology·Anna R ThornerDan H Barouch
Nov 17, 2006·Journal of Virology·Milena Iacobelli-Martinez, Glen R Nemerow
May 31, 2007·The Journal of Experimental Medicine·Melissa L PrecopioRichard A Koup
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karin LoréRichard A Koup
Mar 26, 2008·Immunology and Cell Biology·Axel Kallies
Dec 9, 2008·Immunology Letters·Cláudio A BonjardimErna G Kroon
Apr 16, 2009·Reviews in Medical Virology·Niklas Arnberg
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nia TatsisMichael R Betts
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew G SikoraWillem W Overwijk
Aug 28, 2009·Journal of Cellular Biochemistry·Anne K ZaissHarvey R Herschman
Nov 13, 2009·Gene Therapy·S Nayak, R W Herzog
Nov 17, 2009·Nature Immunology·William R Heath, Francis R Carbone

❮ Previous
Next ❯

Citations

Nov 30, 2012·Immunology and Cell Biology·Christian Engwerda, Gabrielle Belz
Jan 1, 2013·Journal for Immunotherapy of Cancer·Hadas Prag NavehLisa H Butterfield
May 3, 2014·The Journal of Clinical Investigation·Ashraful HaqueChristian R Engwerda
Mar 4, 2014·Human Gene Therapy·Dragomira MajhenJerome Custers
Feb 26, 2016·Proceedings of the National Academy of Sciences of the United States of America·Colin Havenar-DaughtonShane Crotty
Feb 3, 2015·The Journal of Clinical Investigation·Kylie M QuinnRobert A Seder
May 11, 2016·Molecular Therapy. Methods & Clinical Development·Sam AfkhamiZhou Xing
Feb 15, 2018·Vaccines·Anne-Marie C AnderssonPeter J Holst
Nov 14, 2018·The Journal of Clinical Investigation·Hongjie WangAndré Lieber
Nov 11, 2019·FEBS Letters·Chang Li, André Lieber
Jul 16, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patricia A DarrahRobert A Seder
Jan 30, 2021·Science·Nicholas M ProvinePaul Klenerman
Jul 28, 2021·The Journal of Clinical Investigation·Ayad AliStephen N Waggoner

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.