Type I interferon gene expression in antiphospholipid syndrome: Pathogenetic, clinical and therapeutic implications

Journal of Autoimmunity
Eleni Xourgia, Maria Tektonidou

Abstract

Type I Interferon gene expression has been shown to play an important role in the pathogenesis of several systemic autoimmune disorders, paving the way for its potential use as a surrogate marker or a therapeutic tool. While the concept of type I interferon signature and its correlation with clinical phenotypes and disease activity, along with anti-interferon targeted therapy have been vastly investigated in patients with systemic lupus erythematosus, there is a paucity of data concerning antiphospholipid syndrome patients. In this review, we summarize the current knowledge on the pathogenetic and clinical implications of type I interferon expression in antiphospholipid syndrome and discuss the therapeutic possibility of targeting molecules along the interferon signaling pathway. A number of recent studies have shown a type I interferon gene expression induction in patients with primary antiphospholipid syndrome via the plasmacytoid dendritic cell pathway, toll like receptors (TLRs) such as TLR7 and TLR9, anti-beta2glycoprotein I antibody-mediated neutrophil activation and neutrophil extracellular traps (NETs) release in a TLR4-dependent fashion, and a subsequent B cell and plasmablast activation. An association between type I ...Continue Reading

References

Jul 5, 1979·The New England Journal of Medicine·J J HooksA L Notkins
Oct 2, 2008·Lupus·R T UrbanusP G de Groot
Mar 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alenka KuznikRoman Jerala
Mar 15, 2013·The New England Journal of Medicine·Bill Giannakopoulos, Steven A Krilis
Aug 2, 2013·Journal of Thrombosis and Haemostasis : JTH·A Schmidt-TanguyC Belizna
Sep 10, 2013·Seminars in Arthritis and Rheumatism·Christos KampolisPanayiotis G Vlachoyiannopoulos
Jun 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary K Crow
Jan 22, 2015·Arthritis & Rheumatology·Danieli AndradeJane E Salmon
Jan 27, 2015·Autoimmunity Reviews·Arsène MekinianUNKNOWN SNFMI and the European Forum on Antiphospholipid Antibodies
Feb 5, 2015·Nature Communications·Atsuo KannoKensuke Miyake
Jul 1, 2015·Current Opinion in Rheumatology·Cecilia Beatrice ChighizolaPier Luigi Meroni
Mar 21, 2016·Current Rheumatology Reports·Danieli Andrade, Maria Tektonidou
Jan 23, 2018·Frontiers in Immunology·Stefano AliverniniMariola Kurowska-Stolarska
Sep 7, 2018·Annals of the Rheumatic Diseases·Lucas L van den HoogenTimothy R D J Radstake
Nov 25, 2018·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Emma WeedingAmr H Sawalha
Feb 18, 2019·Autoimmunity Reviews·Michelle Remião Ugolini-LopesDanieli Castro Oliveira de Andrade
Mar 14, 2019·Journal of Thrombosis and Haemostasis : JTH·Ryo HisadaTatsuya Atsumi
Mar 30, 2019·Frontiers in Immunology·Shruti ChaturvediKeith R McCrae
Apr 25, 2019·Nature Communications·Ramadan A AliJason S Knight
May 17, 2019·Annals of the Rheumatic Diseases·Maria G TektonidouMichael M Ward

❮ Previous
Next ❯

Citations

Mar 19, 2020·Current Opinion in Rheumatology·Jacqueline A MadisonJason S Knight
Jul 24, 2020·Current Rheumatology Reports·Eleni Xourgia, Maria G Tektonidou
Aug 28, 2020·Current Rheumatology Reports·Ajay TambralliJason S Knight
Jan 28, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Christian A DevauxDidier Raoult
Jun 12, 2021·Nature Communications·Perrine SoretJacques-Olivier Pers
Jun 7, 2021·Cytokine & Growth Factor Reviews·Rossella Talotta, Erle S Robertson

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.