Type I Interferon Inhibition of MicroRNA-146a Maturation Through Up-Regulation of Monocyte Chemotactic Protein-Induced Protein 1 in Systemic Lupus Erythematosus

Arthritis & Rheumatology
Bo QuNan Shen

Abstract

Systemic lupus erythematosus (SLE) is characterized by the uncontrolled production of inflammatory cytokines, among which type I interferon (IFN) is recognized as a crucial pathogenic factor. The expression of microRNA-146a (miR-146a) is reduced in the white blood cells of SLE patients and accounts for their overactivated inflammatory responses. However, the mechanism of the reduction of miR-146a is still not fully understood. This study was undertaken to test whether the key pathogenic cytokine, type I IFN, is responsible for the dysregulation of miR-146a in SLE. Gene and protein expression was measured in all cells by reverse transcription-quantitative polymerase chain reaction, Northern blotting, or Western blotting. In THP-1 cells, expression of monocyte chemotactic protein-induced protein 1 (MCPIP-1) was knocked down with a lentivirus encoding a short hairpin RNA targeting MCPIP1. The cells were pretreated with type I IFN and assessed for gene expression levels of miR-146a. White blood cells from patients with SLE were analyzed for the expression of the IFN-inducible genes MCPIP1 and miR-146a, and the gene expression data were compared for correlation. Pretreatment of THP-1 cells with type I IFN attenuated the induction of...Continue Reading

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Citations

Oct 27, 2016·Particle and Fibre Toxicology·Haijun LiuJie Chao
Jun 2, 2017·Current Opinion in Rheumatology·Xiong LeNan Shen
Oct 7, 2017·Current Rheumatology Reports·Yun Deng, Betty P Tsao
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Feb 15, 2017·Cellular & Molecular Immunology·Renfang MaoYihui Fan
Nov 7, 2018·International Journal of Rheumatic Diseases·Majid KhoshmirsafaMehdi Shekarabi
Jan 13, 2021·Arthritis Research & Therapy·Barbara StypińskaAgnieszka Paradowska-Gorycka
Jan 21, 2021·International Journal of Molecular Sciences·Shiyi Tan, Shi Chen
Apr 16, 2021·Bone Reports·Mingxia ZhengXiaogang Wang

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