Type I interferons and endoplasmic reticulum stress in health and disease

International Review of Cell and Molecular Biology
Jenny Sprooten, Abhishek D Garg

Abstract

Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed, by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing to this broad range of influence, type I IFNs also exhibit critical functions in many sterile inflammatory diseases and immunopathologies, especially those associated with endoplasmic reticulum (ER) stress-driven signaling pathways. Indeed, over the years accumulating evidence has indicated that the presence of ER stress can influence the production, or sensing of, type I IFNs induced by perturbations like pattern recognition receptor (PRR) agonists, infections (bacterial, viral or parasitic) or autoimmunity. In this article we discuss the link between type I IFNs and ER stress in various diseased contexts. We describe how ER stress regulates type I IFNs production or sensing, or how type I IFNs may induce ER stress, in various circumstances like microbial infections, autoimmunity, diabetes, cancer and other ER stress-related contexts.

Citations

Aug 6, 2020·Cells·Jenny SprootenAbhishek D Garg
Jan 15, 2021·Viruses·Jerome E Tanner, Caroline Alfieri
Jun 3, 2021·Cells·Lorenzo Galluzzi, Abhishek D Garg
Jun 21, 2021·European Journal of Pharmacology·Yihong WanXingang Yao
Aug 21, 2021·International Journal of General Medicine·Shijun PengZhilin Guo
Aug 20, 2021·Oncoimmunology·Takahiro YamazakiLorenzo Galluzzi
Aug 31, 2021·The EMBO Journal·Daniel J KlionskyFederico Pietrocola
Nov 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Carolyn BomidiSarah E Blutt

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Methods Mentioned

BETA
glycosylations
ubiquitination
protein-folding

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