Type I interferons have no major influence on humoral autoimmunity in rheumatoid arthritis

Rheumatology
T CantaertD Baeten

Abstract

Type I IFNs have recently been implicated in autoantibody-mediated diseases such as SLE. As half the RA patients display a type I IFN(high) signature, we investigated in a pilot study if type I IFN determines the autoantibody response in RA. Serum and peripheral blood cells were obtained from 52 RA patients, with paired samples before and after infliximab treatment in 21 patients. Additional samples were collected from 8 anti-citrullinated protein antibody (ACPA)-positive individuals without arthritis and from 10 ACPA-negative healthy controls. The type I IFN signature was determined by peripheral blood cell gene expression analysis and quantitative RT-PCR. ACPA IgG and IgM, RF IgM, anti-nucleosome IgM and anti-dsDNA were measured by ELISA. The type I IFN signature was not related to the presence and titers of ACPA and RF during active disease. TNF blockade induced a similar rise of ANAs, and a similar decrease in RF titers in both groups. ACPA IgG and IgM levels appeared to be down-modulated only in the type I IFN(low) group. These changes were independent of the changes in type I IFN response gene activity after TNF blockade. Furthermore, the ACPA response in individuals without arthritis and inflammation was not related to a...Continue Reading

References

Jul 28, 2001·Trends in Immunology·L Rönnblom, G V Alm
Feb 27, 2003·Journal of Autoimmunity·Déborah BraunJocelyne Demengeot
Mar 19, 2003·The Journal of Experimental Medicine·Lynda BennettVirginia Pascual
Mar 19, 2003·The Journal of Experimental Medicine·Marie-Laure Santiago-RaberArgyrios N Theofilopoulos
Aug 9, 2003·Arthritis and Rheumatism·Geraldine CambridgeAnthony D B Webster
Sep 9, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Paul Peter Tak
Dec 14, 2004·Arthritis and Rheumatism·Kyriakos A KirouMary K Crow
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·A Karolina PaluckaJacques Banchereau
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexis MathianSophie Koutouzov
Apr 22, 2005·Annals of the Rheumatic Diseases·M C Dall'eraJ C Davis
Oct 4, 2005·Arthritis and Rheumatism·Kirsten N VerpoortRene E M Toes
Feb 17, 2006·The New England Journal of Medicine·Helen GogasJohn M Kirkwood
Sep 19, 2006·Immunity·Jacques Banchereau, Virginia Pascual
Nov 23, 2006·Current Opinion in Immunology·Wei Cao, Yong-Jun Liu
Nov 30, 2006·Arthritis and Rheumatism·Blanca RuedaJavier Martín
May 5, 2007·Nature Medicine·Roberto BaccalaArgyrios N Theofilopoulos
Aug 1, 2007·Arthritis and Rheumatism·Johnny C LorentzenSigbjörn Fossum
Sep 6, 2007·Annals of the New York Academy of Sciences·Francesca Bobbio-PallaviciniCarlomaurizio Montecucco
Sep 26, 2007·Immunity·Andreas Pichlmair, Caetano Reis e Sousa
Dec 25, 2007·Pharmacology & Therapeutics·Daniel TraceyPaul P Tak
Jan 30, 2008·Arthritis Research & Therapy·Martin Aringer, Josef S Smolen

❮ Previous
Next ❯

Citations

Nov 11, 2010·Arthritis Research & Therapy·Tineke CantaertLisa G M van Baarsen
May 1, 2012·Arthritis Research & Therapy·Hennie G RatermanAlexandre E Voskuyl
Sep 13, 2011·Journal of Autoimmunity·Andrea T BorchersM Eric Gershwin
Jun 18, 2014·Journal of Autoimmunity·Sonia Berrih-Aknin
Nov 19, 2014·PloS One·Jadwiga BienkowskaJeffrey L Browning
Jul 3, 2018·Biomedit︠s︡inskai︠a︡ khimii︠a︡·E V Chetina, G A Markova
Mar 14, 2020·Arthritis Research & Therapy·Waka Yokoyama-KokuryoMasayoshi Harigai
May 16, 2019·Tuberculosis·Jorge L CervantesXavier Roca
Mar 31, 2011·Current Opinion in Rheumatology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.