Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge.

Immunity
Jacob E KohlmeierDavid L Woodland

Abstract

Memory CD8(+) T cells in the lung airways provide protection from secondary respiratory virus challenge by limiting early viral replication. Here, we demonstrate that although airway-resident memory CD8(+) T cells were poorly cytolytic, memory CD8(+) T cells recruited to the airways early during a recall response showed markedly enhanced cytolytic ability. This enhanced lytic activity did not require cognate antigen stimulation, but rather was dependent on STAT1 transcription factor signaling through the interferon-alpha receptor (Ifnar1), resulting in the antigen-independent expression of granzyme B protein in both murine and human virus-specific T cells. Signaling through Ifnar1 was required for the enhanced lytic activity and control of early viral replication by memory CD8(+) T cells in the lung airways. These findings demonstrate that innate inflammatory signals act directly on memory T cells, enabling them to rapidly destroy infected host cells once they enter infected tissues.

References

Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P A MossJ I Bell
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Barbara J JohnsonAnne Kelso
Jan 5, 2005·Nature Reviews. Immunology·Jo Rae Wright
Nov 23, 2005·The Journal of Experimental Medicine·Godelieve J de BreeRené A W van Lier
May 19, 2006·European Journal of Immunology·Simone VallbrachtStephan Ehl
Jun 16, 2006·Journal of Virology·Ana Fernandez-SesmaThomas M Moran
Jan 12, 2008·Science·Linda M WakimFrancis R Carbone
Oct 29, 2008·Annual Review of Immunology·Jacob E Kohlmeier, David L Woodland
Feb 26, 2009·Nature Reviews. Immunology·David L Woodland, Jacob E Kohlmeier

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Citations

Jul 27, 2011·The Journal of Experimental Medicine·Jacob E KohlmeierDavid L Woodland
Mar 7, 2012·The Journal of Experimental Medicine·Oludare A OdumadeKristin A Hogquist
Mar 6, 2013·The Journal of Experimental Medicine·Shlomo Z Ben-SassonWilliam E Paul
Apr 17, 2010·American Journal of Respiratory and Critical Care Medicine·Claudie Bantsimba-MalandaPaul Soler
Jun 10, 2011·American Journal of Respiratory Cell and Molecular Biology·Daniel KreiselAlexander S Krupnick
Jan 19, 2012·The Journal of Clinical Investigation·Barbara DrobitsMaria Sibilia
Mar 3, 2012·PLoS Pathogens·Sophie A ValkenburgKatherine Kedzierska
Oct 25, 2013·Viruses·Jason Netland, Michael J Bevan
Apr 26, 2014·Nature Reviews. Immunology·Akiko Iwasaki, Padmini S Pillai
Oct 15, 2011·Immunotherapy·Jeffrey C NolzJohn T Harty
Mar 28, 2012·Biomarkers in Medicine·Cassandra M BerryNiamh E Mangan
Feb 11, 2014·The Journal of Clinical Investigation·Jeffrey C Nolz, John T Harty
Jul 22, 2014·Trends in Immunology·Nicole L La Gruta, Stephen J Turner
Jun 1, 2014·Cellular and Molecular Life Sciences : CMLS·Laure Ysebrant de LendonckStanislas Goriely
May 10, 2011·Annual Review of Nutrition·Elizabeth M GardnerDavid M Duriancik
Jun 1, 2013·Current Opinion in Virology·M L B HillaireJ H C M Kreijtz
Aug 21, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Hannah L MillerJohn F McDyer
Nov 29, 2011·Veterinary Immunology and Immunopathology·R ChannappanavarA B Pandey
Mar 24, 2012·Current Opinion in Virology·Andreas WackAnne O'Garra
Jul 15, 2011·Current Opinion in Immunology·Carolina B López, Tamar Hermesh
Dec 20, 2014·Immunity·Jason M Schenkel, David Masopust
Dec 22, 2015·Cytokine·Stefanie F ValbonMartin J Richer
Mar 3, 2011·Journal of Internal Medicine·K K McKinstryS L Swain
Jun 16, 2011·European Journal of Immunology·Ashraful HaqueChristian R Engwerda
Feb 16, 2011·Immunology·Jonathan P Huber, J David Farrar
Apr 20, 2011·Cellular Microbiology·Noah S ButlerJohn T Harty
Aug 21, 2015·Journal of Translational Medicine·Yichun ZhuXiangdong Wang

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