Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.

The Journal of Biological Chemistry
J C Loijens, R A Anderson

Abstract

Phosphatidylinositol-4-phosphate 5-kinases (PIP5K) synthesize phosphatidylinositol-4,5-bisphosphate, a key precursor in phosphoinositide signaling that also regulates some proteins and cellular processes directly. Two distinct PIP5Ks have been characterized in erythrocytes, the 68-kDa type I (PIP5KI) and 53-kDa type II (PIP5KII) isoforms. Using peptide sequences from the erythroid 68-kDa PIP5KI, we have isolated cDNAs encoding PIP5KIalpha from human brain. Partial cDNAs obtained for a second isoform, PIP5KIbeta, established that the human STM7 gene encoded a previously unrecognized PIP5KI. However, the peptide sequences demonstrated that erythroid PIP5KI corresponded to PIP5KIalpha. Recombinant, bacterially expressed PIP5KIalpha possessed PIP5K activity and was immunoreactive with erythroid PIP5KI antibodies. By Northern analysis, PIP5KIalpha and PIP5KIbeta had wide tissue distributions, but their expression levels differed greatly. PIP5KIs had homology to the kinase domains of PIP5KIIalpha, yeast Mss4p and Fab1p, and a new Caenorhabditis elegans Fab1-like protein identified in the data base. These new isoforms have refined the sequence requirements for PIP5K activity and, potentially, regulation of these enzymes. Furthermore, ...Continue Reading

References

Jan 1, 1990·Journal of Neurochemistry·A MoritzK W Wirtz
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A LemmonJ Schlessinger
Aug 1, 1995·Human Molecular Genetics·J J CarvajalS Chamberlain
Jul 28, 1995·The Journal of Biological Chemistry·K F ToliasC L Carpenter
Jan 1, 1995·Current Biology : CB·L S PriceA Koffer
Jun 16, 1995·Cell·M P PeppelenboschJ L Bos
Feb 17, 1995·The Journal of Biological Chemistry·I V Boronenkov, R A Anderson
Mar 1, 1994·Molecular & General Genetics : MGG·S YoshidaY Anraku
Jan 1, 1996·Advances in Enzyme Regulation·J C LoijensR A Anderson

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Citations

Jan 25, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Paschal A Oude WeerninkMartina Schmidt
May 24, 2007·Pflügers Archiv : European journal of physiology·Yuntao S Mao, Helen L Yin
Mar 26, 1998·Biochimica Et Biophysica Acta·T MunnikA Musgrave
Jun 8, 1999·Chemistry and Physics of Lipids·K F Tolias, L C Cantley
Jun 7, 2003·Advances in Enzyme Regulation·Yasunori KanahoMasakazu Yamazaki
Sep 2, 1999·Advances in Enzyme Regulation·C L CarpenterJ Hartwig
Apr 30, 1998·Current Opinion in Cell Biology·A Toker
Apr 8, 1998·Current Opinion in Genetics & Development·X D Ren, M A Schwartz
Jun 1, 1997·Current Opinion in Neurobiology·T F Martin
Mar 17, 2004·Brain Research. Gene Expression Patterns·Yosuke AkibaHisatake Kondo
Aug 19, 2000·The Biochemical Journal·W E HughesP J Parker
Oct 1, 1998·The Plant Journal : for Cell and Molecular Biology·K MikamiK Shinozaki
Sep 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yanfeng WangCharles S Abrams
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yasuko NodaNobutaka Hirokawa
Jul 14, 2010·The Journal of Biological Chemistry·Laura A Volpicelli-DaleyPietro De Camilli
Jan 11, 2011·The Journal of Biological Chemistry·Yung-Luen YuMien-Chie Hung
Mar 16, 2005·The Journal of Experimental Medicine·Junko SasakiYasunori Kanaho
Aug 27, 2005·Molecular Biology of the Cell·P D AroraC A McCulloch
May 22, 2007·Biochemistry. Biokhimii︠a︡·N A Karataeva, G A Nevinsky
Oct 6, 1998·Annual Review of Biochemistry·D A FrumanL C Cantley
Dec 13, 2007·Blood·Federica MicucciRicciarda Galandrini
Oct 17, 2009·BMC Evolutionary Biology·Yong ZhangLiping Wei
Sep 11, 2007·Biological & Pharmaceutical Bulletin·Yasunori KanahoTakeaki Yokozeki
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rushika M PereraDerek Toomre
Jul 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yanfeng WangCharles S Abrams
Jul 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Julius SemenasJenny L Persson
Jun 19, 2010·Cellular and Molecular Life Sciences : CMLS·Katarzyna Kwiatkowska
Mar 14, 1998·The Journal of Cell Biology·C D'Souza-SchoreyP J Peters
Sep 29, 2011·Advances in Biological Regulation·Yasunori Kanaho, Takamitsu Unoki

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