Type I pityriasis rubra pilaris: upregulation of tumor necrosis factor alpha and response to adalimumab therapy

Journal of Cutaneous Medicine and Surgery
Yao-Hua ZhangZhi-Zhong Zheng

Abstract

pityriasis rubra pilaris (PRP) has unknown etiology and is often refractory to conventional therapies. to document a PRP patient's response to adalimumab therapy and to highlight the potential role of tumor necrosis factor (TNF) in the development of PRP skin lesions. a patient received adalimumab therapy at standard dosing intervals. In addition, the messenger ribonucleic acid (mRNA) of TNF in the lesional and perilesional normal skin was quantified in two patients with PRP. the patient responded to adalimumab therapy and achieved clinical remission by 4 months. There was a significant elevation of TNF mRNA in the lesional skin of PRP. TNF upregulation is detected in PRP lesional skin, consistent with the observed clinical efficacy of TNF blockade for the treatment of PRP.

References

Mar 1, 1980·Clinical and Experimental Dermatology·W A Griffiths
Mar 5, 1999·International Journal of Dermatology·M R Albert, B T Mackool
Jun 3, 1999·The British Journal of Dermatology·A González-LópezA Del Villar
Dec 12, 2001·Pediatric Dermatology·I BetllochJ Bañuls
Jun 3, 2004·Rheumatic Diseases Clinics of North America·Edward Keystone, Boulos Haraoui
Aug 26, 2004·The British Journal of Dermatology·A-L ChewB Kirkham
Apr 20, 2005·Archives of Dermatology·Wennie C Liao, Diya F Mutasim
May 13, 2005·The British Journal of Dermatology·M J SladdenP E Hutchinson
Apr 28, 2006·The Australasian Journal of Dermatology·Shobhan ManoharanKrishna Gumparthy
Nov 9, 2007·Acta Dermato-venereologica·Diana P Ruiz-GenaoFernando Pinedo-Moraleda
Dec 18, 2007·The British Journal of Dermatology·D SeckinT Ergun
Dec 19, 2007·Archives of Dermatology·Kristy F DavisAzin Meshkinpour
Dec 5, 2008·The New England Journal of Medicine·Paolo Sfriso, Francesca Ravaioli
Jan 6, 2009·Journal of the American Academy of Dermatology·Veronica CoxTerence C O'Grady
Jan 21, 2009·Archives of Dermatology·Hobart W Walling, Brian L Swick

❮ Previous
Next ❯

Citations

Nov 28, 2013·Pharmaceuticals·David Chandler, Anthony Bewley
Dec 17, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·S Roenneberg, T Biedermann
Dec 7, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Christian KromerRotraut Mössner
Mar 29, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Christian KromerRotraut Mössner
Mar 21, 2015·Ophthalmic Plastic and Reconstructive Surgery·Anjana S Haridas, Timothy J Sullivan
Jun 6, 2020·American Journal of Hematology·Ruby B KwakVinod E Nambudiri
Jul 25, 2012·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·U Wollina
Jan 6, 2018·American Journal of Clinical Dermatology·Dingyuan WangHazel H Oon

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cutaneous Medicine and Surgery
Joshua M MercerIan D R Landells
Dermatology : International Journal for Clinical and Investigative Dermatology
K UsukiT Kanzaki
Journal of the American Academy of Dermatology
Dawn S AllisonC H Dicken
Journal of Medical Case Reports
Stamatis GregoriouGeorge Kontochristopoulos
Dermatology : International Journal for Clinical and Investigative Dermatology
S SharmaB Paulger
© 2021 Meta ULC. All rights reserved