Type II and type III deiodinase activity in human placenta as a function of gestational age

The Journal of Clinical Endocrinology and Metabolism
J M Koopdonk-KoolTheo J Visser

Abstract

Thyroid hormones are essential for fetal development. T4 can be activated by type I (ID-I) and type II (ID-II) iodothyronine deiodinase or inactivated by type III deiodinase (ID-III). The influence of placental ID-II and ID-III on the regulation of fetal thyroid hormone levels was investigated. Using [125I]T4 and [125I]T3, respectively, ID-II and ID-III activities were measured in homogenates of normal human placentas from 6-43 weeks gestational age and in placentas from five term neonates with a total thyroid hormone synthesis defect. ID-II and ID-III activities related to protein or DNA concentration decreased and total placental ID-III activity increased significantly during pregnancy, whereas the increase in total placental ID-II activity was not significant. Absolute placental ID-II activity was approximately 200 times lower than ID-III activity at all gestational ages. Therefore, fluctuations in ID-II activity were not likely to have a significant influence on fetal thyroid hormone concentrations, but may play a role in the regulation of intraplacental T3 generation. The high ID-III activity most likely influences the thyroid hormone economy of the fetus. Severely hypothyroid newborns showed strongly decreased serum T4 le...Continue Reading

Citations

Jan 18, 2006·The Journal of Clinical Investigation·Arturo HernandezDonald St Germain
Apr 9, 1999·The Journal of Clinical Investigation·V A GaltonD L St Germain
Apr 9, 2002·Journal of Endocrinological Investigation·J Bernal
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Nov 26, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Ulla Feldt-Rasmussen, Elisabeth R Mathiesen
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Feb 6, 2017·Molecular and Cellular Endocrinology·Kelly Landers, Kerry Richard
Sep 11, 2019·Biological Trace Element Research·Shiqiao PengWeiping Teng
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Rosa M CalvoGabriella Morreale de Escobar
May 30, 2003·American Journal of Physiology. Endocrinology and Metabolism·Monique H A KesterTheo J Visser
Jun 3, 2021·Cancers·Gabriella SchieraItalia Di Liegro

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