PMID: 8945077Nov 1, 1996Paper

Type II atrial flutter interruption with transesophageal pacing: use of propafenone and possible change of the substrate

Pacing and Clinical Electrophysiology : PACE
F DoniC Fiorentini

Abstract

Type II atrial flutter (AFII) is an arrhythmia which usually cannot be interrupted by atrial pacing: the underlying mechanism is considered to be a leading circle without an excitable gap. We investigated whether the administration of propafenone, an antiarrhythmic drug, which primarily decreases conduction velocity, has a beneficial effect on AFII interruption using transesophageal pacing. Twelve patients with an AFII were randomized into 2 groups in which pacing was performed without treatment (group A) or two hours after the administration of 600 mg of oral propafenone (group B). Sinus rhythm was attained in 0 of 6 patients in group A and in 4 of 6 patients in group B (P < 0.05). The baseline mean cycle length was the same in both groups (175 +/- 7 (A) vs 168 +/- 8 ms (B); it lengthened significantly after the administration of propafenone (219 +/- 33 vs 168 +/- 8 ms; P < 0.05). Propafenone did not significantly lengthen the cycle in the two patients in whom interruption of the arrhythmia was impossible. Our data show that propafenone has a facilitating effect on atrial pacing only when it significantly prolongs the cycle length of the arrhythmia, possible expression of a conversion of AFII into type I, with an anatomical su...Continue Reading

References

Sep 1, 1987·Pacing and Clinical Electrophysiology : PACE·D C ChungJ Cooper
Jun 1, 1989·American Heart Journal·M GuarnerioM Disertori
Jun 1, 1989·The American Journal of Medicine·W CrawfordG N Kay
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Citations

Feb 16, 2005·Current Problems in Cardiology·Ken W LeeUNKNOWN University of Califoirnia-San Francisco, San Francisco, CA, USA
Dec 22, 2004·Journal of Cardiovascular Electrophysiology·Philippe Maury, Marc Zimmermann

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