Type IIA Secreted Phospholipase A2 in Host Defense against Bacterial Infections.

Trends in Immunology
Vincent P van HensbergenLhousseine Touqui

Abstract

The enzyme type IIA secreted phospholipase A2 (sPLA2-IIA) is crucial for mammalian innate host defense against bacterial pathogens. Most studies have investigated the role of sPLA2-IIA in systemic bacterial infections, identifying molecular pathways of bacterial resistance against sPLA2-IIA-mediated killing, and providing insight into sPLA2-IIA mechanisms of action. Sensitization of (antibiotic-resistant) bacteria to sPLA2-IIA action by blocking bacterial resistance or by applying sPLA2-IIA to treat bacterial infections might represent a therapeutic option in the future. Because sPLA2-IIA is highly expressed at mucosal barriers, we also discuss how sPLA2-IIA is likely to be an important driver of microbiome composition; we anticipate that future research in this area may bring new insights into the role of sPLA2-IIA in health and disease.

References

Jan 1, 1991·Histochemistry·S J DesaiM G Deo
Apr 1, 1989·Annals of the Rheumatic Diseases·H Gonzalez-BuriticaG R Hughes
Sep 22, 1995·The Journal of Biological Chemistry·B P KennedyW A Cromlish
Nov 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E M Rintala, T J Nevalainen
Mar 13, 1999·The Journal of Clinical Investigation·A K Foreman-WykertJ Weiss
Sep 1, 1999·European Journal of Biochemistry·H SawadaI Kudo
Feb 15, 2001·Annals of Surgery·H FriessM W Büchler
Mar 2, 2002·The Lancet Infectious Diseases·R E Hancock
Mar 20, 2002·Current Molecular Medicine·L Touqui, M Alaoui-El-Azher
Jun 27, 2002·The Journal of Infectious Diseases·Juha O GrönroosTimo J Nevalainen
Sep 24, 2002·The Journal of Biological Chemistry·Sofiane BezzineMichael H Gelb
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eric BoilardMarc E Surette
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jon K FemlingJerrold P Weiss
Oct 29, 2005·Scandinavian Journal of Immunology·J O GrönroosV J O Laine
Oct 29, 2005·The Lancet Infectious Diseases·Jonathan R CarapetisMartin Weber
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alejandro Piris-GimenezPierre L Goossens
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Massimo TriggianiGianni Marone
Dec 12, 2007·PLoS Pathogens·Benoit RaymondLhousseine Touqui
Jan 8, 2008·Biochimica Et Biophysica Acta·Timo J NevalainenKieran F Scott
Apr 15, 2008·Annual Review of Biochemistry·Gérard Lambeau, Michael H Gelb
Nov 18, 2008·Journal of Lipid Research·John E Burke, Edward A Dennis
Mar 18, 2009·Antimicrobial Agents and Chemotherapy·Soo-Jin YangArnold S Bayer

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Citations

Feb 23, 2020·The Journal of Pathology·Siamon GordonSubhankar Mukhopadhyay
Oct 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ryung Rae KimW Bret Church
Apr 10, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·S RajasekaranKanna Rishi Mugesh
Jun 10, 2021·Cell Biochemistry and Biophysics·Eleftheria LetsiouSteven M Dudek
Sep 4, 2021·Biomedical Journal·Eirini KitsiouliMarilena E Lekka
Aug 25, 2021·The Journal of Clinical Investigation·Justin M SniderFloyd H Chilton
May 27, 2021·Current Pharmaceutical Design·Wheeler TorresValmore Bermudez

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