Type III collagen aminopropeptide and laminin P1 levels in serum of patients with silicosis-associated and idiopathic systemic scleroderma

The British Journal of Dermatology
K HerrmannT Krieg

Abstract

A group of 191 patients with systemic scleroderma and 12 patients with silicosis-associated scleroderma were investigated for connective tissue turnover. The serum levels of type III collagen aminopropeptide (P-III-P), the laminin PI (Lam PI) fragment and the acid lysosomal beta-galactosidase (beta-Gal) were determined by specific radioimmunoassays and spectrofluorometry, respectively. Increased levels of type III collagen aminopropeptide strongly correlated with enhanced activity of beta-galactosidase. Both parameters correlated with the clinical course in idiopathic systemic scleroderma and in silicosis-associated scleroderma. Serum levels of Lam PI were also found to be elevated in both groups, although there was no correlation with the severity of the disease. Autoantibodies directed against the DNA topoisomerase Scl-70 and against centromeric proteins were found in a similar range in patients with idiopathic systemic and silicosis-associated scleroderma. These results suggest that P-III-P, Lam PI and beta-Gal are useful serological markers of fibrotic activity and demonstrate similarities between idiopathic systemic scleroderma and scleroderma associated with silica-dust exposure.

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Citations

Jan 1, 1994·Archives of Dermatological Research·K KikuchiK Takehara
Dec 1, 1993·British Journal of Industrial Medicine·P HotzR Lauwerys
Apr 1, 1994·Clinics in Dermatology·M Matucci-CerinicT Lotti
Jul 1, 1994·Clinics in Dermatology·U F Haustein, K Herrmann
Nov 16, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Stefanie ReichKlaus Hoffmann
May 28, 2019·International Journal of Molecular Sciences·Suni LeeTakemi Otsuki
Jan 1, 1993·The Journal of Investigative Dermatology·C MauchT Krieg

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