Type IV hypersensitivity to vitamin K

Contact Dermatitis
Sabine SommerCaroline Wilson

Abstract

The day after intramuscular injection of vitamin K1 (phytomenadione) into her thigh, a 27-year-old-woman with normal liver function developed a relapsing and remitting eczematous reaction localized to the injection site, and later a further eczematous reaction under an adhesive dressing (Duoderm). On patch testing, she was positive to vitamin K1 and cross-reacted to vitamin K4; she was also positive to colophonium and to ester gum rosin, the dressing adhesive. Recurrent angioedema persisted for several months and, 2 years later, symptoms were still occurring over the injection sites. Structure-activity relationships among vitamin K allergens are discussed.

References

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Citations

Feb 24, 2005·Contact Dermatitis·Leonardo VenezianoAntonella Tosti
Sep 9, 2006·Contact Dermatitis·Francisco Javier Ruiz-HornillosMaría Rubio Sotés
May 4, 2010·Contact Dermatitis·Juan García-GavínDominique Tennstedt
Apr 30, 2004·British Journal of Community Nursing·H J Schulze

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