Type IV secretion systems: versatility and diversity in function.

Cellular Microbiology
Karin WalldenGabriel Waksman

Abstract

Type IV secretion systems (T4SSs) are large protein complexes which traverse the cell envelope of many bacteria. They contain a channel through which proteins or protein-DNA complexes can be translocated. This translocation is driven by a number of cytoplasmic ATPases which might energize large conformational changes in the translocation complex. The family of T4SSs is very versatile, shown by the great variety of functions among family members. Some T4SSs are used by pathogenic Gram-negative bacteria to translocate a wide variety of virulence factors into the host cell. Other T4SSs are utilized to mediate horizontal gene transfer, an event that greatly facilitates the adaptation to environmental changes and is the basis for the spread of antibiotic resistance among bacteria. Here we review the recent advances in the characterization of the architecture and mechanism of substrate transfer in a few representative T4SSs with a particular focus on their diversity of structure and function.

References

Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A NicosiaR Rappuoli
Jan 1, 1986·Annual Review of Genetics·K A Ippen-Ihler, E G Minkley
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A A WeissD L Burns
Jul 31, 1999·The Journal of Biological Chemistry·R EisenbrandtE Lanka
Oct 16, 1999·FEMS Microbiology Letters·K A Craig-Mylius, A A Weiss
Sep 24, 2002·The Journal of Biological Chemistry·Itsaso HormaecheFernando De La Cruz
Mar 5, 2003·Current Opinion in Microbiology·Drusilla L Burns
May 3, 2003·The EMBO Journal·Savvas N SavvidesGabriel Waksman
Jun 5, 2003·Cellular Microbiology·Jiro TanakaChihiro Sasakawa
Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Elisabeth GrohmannManuel Espinosa
Jun 26, 2003·Molecular Microbiology·Manfred RohdeRainer Haas
Jul 12, 2003·FEMS Microbiology Letters·T D LawleyL S Frost
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hye-Jeong YeoGabriel Waksman
May 25, 2004·Science·Eric Cascales, Peter J Christie
Mar 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Laurent TerradotGabriel Waksman
May 20, 2005·The Journal of Biological Chemistry·Qing YuanChristian Baron
Sep 13, 2005·Annual Review of Microbiology·Peter J ChristieEric Cascales
Feb 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Susan BaileyPatricia C Zambryski
Mar 15, 2006·Current Opinion in Microbiology·Steffen Backert, Thomas F Meyer
May 30, 2006·Journal of Molecular Biology·Stephen HareGabriel Waksman
Oct 17, 2006·Molecular Microbiology·Carr D VincentJoseph P Vogel
Jul 17, 2007·Journal of Bacteriology·John ZupanPatricia Zambryski
Jul 17, 2007·Trends in Microbiology·Shira Ninio, Craig R Roy
Nov 3, 2007·Microbiology·Khaled A Aly, Christian Baron
Mar 15, 2008·Science·Ana BabicMiroslav Radman
Apr 16, 2008·Cellular Microbiology·Steffen Backert, Matthias Selbach
Jun 5, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·An-Chi ShuTri-Rung Yew
Jun 10, 2008·Journal of Bacteriology·Ignacio ArechagaFernando de la Cruz
Jun 14, 2008·Cellular Microbiology·Mario JuhasDerek W Hood

❮ Previous
Next ❯

Citations

Jun 28, 2011·Antonie van Leeuwenhoek·Lyudmila BoyanovaIvan Mitov
Apr 2, 2013·Research in Microbiology·Minny BhattyPeter J Christie
Jun 30, 2012·Proceedings of the National Academy of Sciences of the United States of America·Karin WalldénGabriel Waksman
Nov 29, 2012·The Journal of Biological Chemistry·Nikolaus Goessweiner-MohrWalter Keller
Nov 30, 2012·Nucleic Acids Research·Dexi BiHong-Yu Ou
Mar 14, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jack C LeoDirk Linke
Feb 7, 2013·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Nikolaus Goessweiner-MohrWalter Keller
Jan 11, 2012·Clinical Microbiology Reviews·Alexander Harms, Christoph Dehio
Jan 16, 2013·Infection and Immunity·Mariela G Del GiudiceCecilia Czibener
Apr 9, 2013·Journal of Bacteriology·Eric CascalesPeter J Christie
Apr 30, 2013·Journal of Bacteriology·Cris Fernández-LópezD Roeland Boer
Apr 17, 2013·BMC Microbiology·Jackeline Lizzeta Arvizu-GómezAriel Álvarez-Morales
Dec 6, 2011·PloS One·Svetlana LockwoodShira L Broschat
Jan 12, 2012·PloS One·Laurent HébertSandrine Petry
Feb 14, 2012·Future Microbiology·Daniel E VothJoseph G Graham
Oct 17, 2013·Plasmid·Nikolaus Goessweiner-MohrElisabeth Grohmann
Aug 30, 2014·FEMS Microbiology Reviews·Joseph J GillespieAbdu F Azad
Sep 17, 2011·Trends in Biochemical Sciences·Jixin Cui, Feng Shao
Jul 19, 2011·Trends in Molecular Medicine·Aurélie RenvoiséDidier Raoult
Aug 19, 2015·Current Opinion in Structural Biology·Dijun DuBen F Luisi
Mar 1, 2011·The FEBS Journal·Laurent Terradot, Gabriel Waksman
Mar 21, 2013·The EMBO Journal·Angel Rivera-CalzadaElena V Orlova
Sep 11, 2013·Biochimica Et Biophysica Acta·Rosa L SeguraItziar Alkorta
Apr 8, 2014·International Journal of Microbiology·Tiago Rinaldi JacobJesus Aparecido Ferro
Jul 19, 2013·Critical Reviews in Microbiology·Mario Juhas
Jul 18, 2015·Genome Announcements·Daniel WibbergDieter Jahn
Mar 3, 2015·Trends in Microbiology·Dijun DuBen F Luisi
Feb 4, 2014·Journal of Proteomics·Daniel J StekhovenChristian H Ahrens
Apr 23, 2016·Scientific Reports·Christian FercherWalter Keller
Oct 18, 2014·Frontiers in Physiology·Anantha HarijithViswanathan Natarajan

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
ICE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Microbiology and Molecular Biology Reviews : MMBR
Cristina E Alvarez-Martinez, Peter J Christie
Nature Reviews. Microbiology
Rémi FronzesGabriel Waksman
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Ellen L ZechnerJoel F Schildbach
© 2021 Meta ULC. All rights reserved