Type V collagen controls the initiation of collagen fibril assembly.

The Journal of Biological Chemistry
Richard J WenstrupDavid E Birk

Abstract

Vertebrate collagen fibrils are heterotypically composed of a quantitatively major and minor fibril collagen. In non-cartilaginous tissues, type I collagen accounts for the majority of the collagen mass, and collagen type V, the functions of which are poorly understood, is a minor component. Type V collagen has been implicated in the regulation of fibril diameter, and we reported recently preliminary evidence that type V collagen is required for collagen fibril nucleation (Wenstrup, R. J., Florer, J. B., Cole, W. G., Willing, M. C., and Birk, D. E. (2004) J. Cell. Biochem. 92, 113-124). The purpose of this study was to define the roles of type V collagen in the regulation of collagen fibrillogenesis and matrix assembly. Mouse embryos completely deficient in pro-alpha1(V) chains were created by homologous recombination. The col5a1-/- animals die in early embryogenesis, at approximately embryonic day 10. The type V collagen-deficient mice demonstrate a virtual lack of collagen fibril formation. In contrast, the col5a1+/- animals are viable. The reduced type V collagen content is associated with a 50% reduction in fibril number and dermal collagen content. In addition, relatively normal, cylindrical fibrils are assembled with a se...Continue Reading

References

Mar 1, 1988·The Journal of Cell Biology·D E BirkT F Linsenmayer
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J M FitchT F Linsenmayer
Jan 1, 1982·Methods in Enzymology·R A Berg
Mar 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D E BirkE I Zycband
May 1, 1994·European Journal of Biochemistry·M Moradi-AméliM Van der Rest
Jul 1, 1995·Matrix Biology : Journal of the International Society for Matrix Biology·A FichardF Ruggiero
Apr 26, 1996·The Journal of Biological Chemistry·R J WenstrupJ B Florer
May 15, 1996·The Biochemical Journal·K E KadlerJ A Chapman
Feb 1, 1996·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·E TilletR Garrone
Jul 1, 1996·Matrix Biology : Journal of the International Society for Matrix Biology·D E BirkE I Zycband
Feb 10, 1997·The Journal of Cell Biology·K G DanielsonR V Iozzo
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·X LiuR Jaenisch
Mar 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D E BirkR L Trelstad
Apr 25, 2000·American Journal of Human Genetics·R J WenstrupW G Cole
Aug 11, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·J ExpositoR Garrone
Jun 29, 2002·The Journal of Biological Chemistry·Karl J JepsenShukti Chakravarti
Apr 20, 2004·Journal of Cellular Biochemistry·Richard J WenstrupDavid E Birk
May 26, 2004·The Journal of Cell Biology·Elizabeth G CantyKarl E Kadler

❮ Previous
Next ❯

Citations

May 16, 2012·Biomechanics and Modeling in Mechanobiology·Jeffrey K Cheng, Jessica E Wagenseil
Oct 11, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Tong Liu, Jian Zhang
Apr 29, 2010·Current Osteoporosis Reports·Roy Morello, Frank Rauch
Nov 10, 2011·Biomacromolecules·Mario RaspantiDésirée Martini
Mar 1, 2008·Eye·M M Le Goff, P N Bishop
Nov 16, 2012·Tissue Engineering. Part a·Cevat EriskenHelen H Lu
Sep 9, 2008·Journal of Biochemistry·Takanori KiharaToshihiko Hayashi
Aug 26, 2006·Current Opinion in Obstetrics & Gynecology·Marianna Alperin, Pamela A Moalli
Sep 18, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Fransiska MalfaitAnne De Paepe
Oct 29, 2010·Cold Spring Harbor Perspectives in Biology·Pepper Schedin, Patricia J Keely
Mar 23, 2011·Cold Spring Harbor Perspectives in Biology·Sylvie Ricard-Blum
Nov 13, 2008·Molecular and Cellular Biology·Yoshihide AsanoMaria Trojanowska
Jul 11, 2006·Annual Review of Cell and Developmental Biology·A AszódiR Fässler
Jun 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Brett S HarrisAmy D Bradshaw
Jul 9, 2009·Physiological Reviews·Jessica E Wagenseil, Robert P Mecham
Aug 28, 2010·Medicine and Science in Sports and Exercise·Michael PosthumusMalcolm Collins
May 21, 2010·PloS One·Dustin BaldridgeRoy Morello
Dec 30, 2011·PloS One·Darren A PlumbRaymond P Boot-Handford
Nov 6, 2014·Nature Reviews. Molecular Cell Biology·Janna K MouwValerie M Weaver
Mar 8, 2014·Journal of Cell Communication and Signaling·Sunil K Parapuram, William Hodge
May 20, 2014·Case Reports in Surgery·Timothy P PlackettRobert C Oh
May 8, 2013·International Urogynecology Journal·Laurent De LandsheereJean-Michel Foidart
Aug 28, 2014·BMC Veterinary Research·Edivaldo A N MartinsLuis C L C Silva
Oct 3, 2014·Journal of the American Podiatric Medical Association·Paul Beeson
Jul 22, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Wei ChenWendy L Frankel
Nov 2, 2005·Obstetrics and Gynecology·Pamela A MoalliLeslie A Meyn

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.