PMID: 8950592Nov 1, 1996Paper

Type VI collagen is present in human and bovine vitreous

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
P BishopC Kielty

Abstract

Heterotypic (mixed) collagen fibrils that contain collagen types II, IX and V/XI have previously been identified in vitreous gel. The purpose of this study was to determine whether vitreous gel also contains type VI collagen microfibrils, as they are widely distributed in other tissues where they may play an important structural role. Bovine and human vitreous gel was analysed by rotary shadowing electron microscopy after bacterial collagenase digestion and gel filtration chromatography. Bovine vitreous was extracted in 4 M guanidine hydrochloride, and following isopycnic centrifugation fractions were analysed by western blotting. Type VI collagen microfibrils were identified by electron microscopy in human and bovine vitreous. Type VI collagen was identified by western blot analysis. Type VI collagen is present in vitreous and may participate in the structural assembly of the vitreous gel.

Citations

Sep 28, 2000·Micron : the International Research and Review Journal for Microscopy·K J BosP N Bishop
Apr 5, 2000·Progress in Retinal and Eye Research·P N Bishop
Mar 1, 2008·Eye·M M Le Goff, P N Bishop
Oct 26, 2000·The British Journal of Ophthalmology·J L AshworthD McLeod
May 29, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Małgorzata NitaDorota Romaniuk
Jul 14, 2010·Progress in Retinal and Eye Research·Theodorus L PonsioenLeonoor I Los
Jun 29, 2004·Progress in Retinal and Eye Research·Tapio IhanamäkiEero Vuorio
Mar 29, 2001·Experimental Eye Research·T IhanamäkiE Vuorio
Nov 2, 2014·Retina·Shao-Chong BuLeonoor I Los
Mar 11, 2020·Progress in Retinal and Eye Research·J Sebag
May 24, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sahar AwwadSteve Brocchini

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