PMID: 9446828Apr 4, 1998Paper

Type VI microfilaments interact with a specific region of banded collagen fibrils in skin

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
D R KeeneR V Iozzo

Abstract

Immunolocalization studies demonstrate that Type VI collagen forms a flexible network that interweaves among collagen fibrils in the dermis of skin as well as in other loose connective tissues. Although binding of Type VI collagen with other matrix components has been suggested, no structural evidence supporting these studies has been reported. In this study, we demonstrate that Type VI microfilaments consistently crossbanded collagen fibrils near the "d" band, indicating that the interaction of Type VI collagen with banded fibrils is not passive. This "d" band is also the location of the binding domain of decorin to banded fibrils, suggesting that decorin mediates the interaction of Type VI microfilaments with banded fibers. Examination of the architecture of the Type VI network in a decorin nullizygous mouse demonstrates a continuance of this specific interaction, indicating that the association is not entirely dependent on the presence of decorin. At least one other component, whose identity is uncertain, persists near the "d" band, which may also serve to mediate the attachment of Type VI collagen to collagen fibrils.

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Citations

Nov 3, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·J VrankaH P Bächinger
Aug 5, 2004·European Journal of Biochemistry·Gordon NareyeckElke Schönherr
Dec 16, 2006·Journal of Cosmetic Dermatology·Rachel E B Watson, Christopher E M Griffiths
Feb 3, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Peter S AmentaJeanne C Myers
Apr 12, 2001·The British Journal of Dermatology·R E WatsonC E Griffiths
May 6, 2006·European Journal of Oral Sciences·Yong-Hee P ChunJames P Simmer
Jul 18, 2006·The Journal of Biological Chemistry·Millicent M SullivanE Helene Sage
Mar 22, 2001·The Journal of Biological Chemistry·C WibergD Heinegård
Jul 4, 2003·The Journal of Biological Chemistry·Charlotte WibergMatthias Mörgelin
Oct 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R Al-Jamal, M S Ludwig

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