Typhoid conjugate vaccines: a new tool in the fight against antimicrobial resistance

The Lancet Infectious Diseases
Jason R AndrewsNathan C Lo

Abstract

Typhoid fever is an acute systemic infectious disease responsible for an estimated 12-20 million illnesses and over 150 000 deaths annually. In March, 2018, a new recommendation was issued by WHO for the programmatic use of typhoid conjugate vaccines in endemic countries. Health economic analyses of typhoid vaccines have informed funding decisions and national policies regarding vaccine rollout. However, by focusing only on averted typhoid cases and their associated costs, traditional cost-effectiveness analyses might underestimate crucial benefits of typhoid vaccination programmes, because the potential effect of typhoid vaccines on the treatment of patients with non-specific acute febrile illnesses is not considered. For every true case of typhoid fever, three to 25 patients without typhoid disease are treated with antimicrobials unnecessarily, conservatively amounting to more than 50 million prescriptions per year. Antimicrobials for suspected typhoid might therefore be an important selective pressure for the emergence and spread of antimicrobial resistance globally. We propose that large-scale, more aggressive typhoid vaccination programmes-including catch-up campaigns in children up to 15 years of age, and vaccination in l...Continue Reading

Citations

Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samantha KaufholdVirginia E Pitzer
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrew J PollardKathleen M Neuzil
Jan 24, 2019·BMJ : British Medical Journal·Christopher M ParryBuddha Basnyat
Aug 31, 2019·EMBO Molecular Medicine·Christoph J BlohmkeThomas C Darton
Dec 6, 2019·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Camilla RotheUNKNOWN Ständiger Ausschuss Reisemedizin (StAR) der Deutschen Gesellschaft für Tropenmedizin und Globale Gesundheit (DTG)
Oct 31, 2019·Praxis·Noëlle Moser-van der GeestLars C Huber
Apr 2, 2020·The American Journal of Tropical Medicine and Hygiene·Grace D AppiahEric D Mintz
Jul 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen BakerThomas C Darton
Feb 26, 2019·The Journal of Experimental Medicine·Peter ReininkIldiko Van Rhijn
Oct 31, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Se Eun ParkFlorian Marks
Jul 14, 2020·Expert Review of Vaccines·María L Avila-AgüeroJosé Brea-Del Castillo
Oct 31, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hyon Jin JeonFlorian Marks
Nov 13, 2020·The Journal of Experimental Medicine·Celina JinAndrew J Pollard
Dec 2, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ashley T LongleyFarah N Qamar
Dec 2, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mohammad T YousafzaiFarah N Qamar
Dec 2, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Farah N QamarSamir K Saha
Dec 11, 2020·Travel Medicine and Infectious Disease·Cristina Masuet-Aumatell, Jorge Atouguia
Apr 14, 2021·Nature Medicine·Jean-Louis ExclerJerome H Kim
Jul 2, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zulfiqar A Bhutta
Sep 17, 2021·The Journal of Infectious Diseases·Samir K SahaSenjuti Saha
Dec 21, 2021·Expert Review of Vaccines·Kimberly M Thompson, Kamran Badizadegan
Jul 18, 2021·The Journal of Infectious Diseases·Jacqueline Deen, John D Clemens
Jan 15, 2022·Annals of the New York Academy of Sciences·Jennifer CableChristopher L Karp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.