Typhoidal Salmonella strains in Pakistan: an impending threat of extensively drug-resistant Salmonella Typhi

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Ashfaq HussainAqeel Peter

Abstract

The aim of this study is to see the frequency, clinical presentation, and therapeutic response of extensively drug-resistant Salmonella enterica serovar Typhi and current susceptibility pattern of typhoidal Salmonella strains in our setup. This study was carried out at the Department of Medical Microbiology and Immunology and Department of Medicine, Pakistan Navy Ship (PNS) Shifa Hospital, Karachi, from January 1 to December 31, 2018. All the blood culture samples of patients (indoor and outdoor) with suspicion of enteric fever were processed. Isolates were cultured and identified using standard microbiological procedures. The antimicrobial sensitivity against the typhoidal Salmonellae was determined using Kirby-Bauer disc diffusion method as per the guidelines of Clinical and Laboratory Standards Institute (2018) and all the extensively drug-resistant (XDR) isolates were confirmed by Vitek 2 system. Clinical presentation and response to treatment of patients were followed. A total of 292 typhoidal Salmonella isolates were cultured. Resistance to ciprofloxacin against both Salmonella Typhi and Salmonella Paratyphi A was found to be very high (91%). Percentage of multidrug-resistant (MDR) isolates in Salmonella Typhi was 76% (18...Continue Reading

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Mar 22, 2018·MBio·Myron M Levine, Raphael Simon
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Citations

Apr 2, 2020·The American Journal of Tropical Medicine and Hygiene·Grace D AppiahEric D Mintz
Aug 11, 2020·Current Opinion in Infectious Diseases·Sneha RadhaPriscilla Rupali
Sep 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George M Varghese
Aug 23, 2020·The Journal of Pediatrics·Pinky Meena, Piyush Gupta
Mar 8, 2021·BMC Infectious Diseases·Hazrat BilalXingyuan Yang
May 27, 2021·Expert Review of Anti-infective Therapy·Zikria SaleemMuhammad Azmi Hassali

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