PMID: 6128681Oct 1, 1982

Typical and atypical neuroleptics are potent antagonists at alpha 1-adrenoceptors of the dorsal lateral geniculate nucleus. An electrophysiological study

Naunyn-Schmiedeberg's Archives of Pharmacology
J Marwaha, G K Aghajanian

Abstract

The present electrophysiology studies examined the actions of neuroleptics at central alpha 1-adrenoceptors in the rat. In single-cell recording experiments, typical and atypical neuroleptics, when administered systemically or locally (iontophoresis and pressure ejection), were found to be potent antagonists of activating alpha 1-adrenoceptor responses in the dorsal lateral geniculate nucleus (dLGN). Doses of neuroleptics effective as antagonists at alpha 1-adrenoceptors had very weak effects at muscarinic receptors in the dLGN. Since doses of neuroleptics employed in the present study were within the clinical range, it appears likely that central alpha 1-adrenoceptors would be blocked during a neuroleptic therapy in humans.

References

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Citations

Nov 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·D B MenkesG K Aghajanian
Jan 1, 1993·Journal of Neural Transmission. General Section·J GrenhoffT H Svensson
Mar 16, 1993·European Journal of Pharmacology·J Grenhoff, T H Svensson
May 1, 1985·Pharmacology, Biochemistry, and Behavior·J Marwaha, A L Curtis
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·G V Rebec, T R Bashore
Jul 1, 1987·Neuropharmacology·A L Curtis, J Marwah

Related Concepts

Nerve Impulses
Adrenergic alpha-Antagonists
Carboptic
Leponex
Electrophysiology (Science)
Medial Geniculate Body
Phenothiazines
Phenylephrine Hydrochloride
August Rats
Sulpor

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