Typical halogenated persistent organic pollutants in indoor dust and the associations with childhood asthma in Shanghai, China

Environmental Pollution
Ge MengYan Wang

Abstract

Halogenated persistent organic pollutants (Hal-POPs) are significant contaminants in the indoor environment that are related to many human diseases. Ingestion of indoor dust is considered the major pathway of Hal-POP exposures, especially for children aged 3-6 years. Alongside a retrospective study on the associations between typical Hal-POP exposure and childhood asthma in Shanghai, indoor dust samples from asthmatic and non-asthmatic children's homes (n = 60, each) were collected. Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) were measured by GC-MS. BDE-209, PCB-8 and p,p'-DDE were the predominant components in each chemical category. The concentrations of most Hal-POPs were significantly higher in the asthmatic families. The associations between Hal-POP exposure and asthma occurrence were examined by calculating the odds ratios (ORs) using a logistic regression model. A positive association was found between p,p'-DDE in indoor dust and childhood asthma (OR = 1.825, 95%CI: 1.004, 3.317; p = 0.048). The average daily doses of Hal-POP intake were calculated using the method provided by the USEPA. Non-carcinogenic health risks were preliminarily assessed. Our study ...Continue Reading

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Citations

Oct 11, 2016·Archives of Toxicology·Sara Mostafalou, Mohammad Abdollahi
Feb 12, 2019·The Journal of Clinical Investigation·Liza Bronner MurrisonGurjit K Khurana Hershey
Feb 2, 2019·The Science of the Total Environment·Biljana D Škrbić, Vesna Marinković

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