PMID: 9431933Feb 12, 1998Paper

Typing of Nocardia farcinica by pulsed-field gel electrophoresis reveals an endemic strain as source of hospital infections

Journal of Clinical Microbiology
J BlümelK P Schaal

Abstract

Severe postoperative wound infections caused by Nocardia farcinica were repeatedly observed in a German hospital surgical ward. A pulsed-field gel electrophoresis (PFGE) protocol was established to characterize the genetic relatedness of the bacterial isolates from these infections. All 18 isolates from postoperative infections that have occurred since 1985 belong to a common endemic genotype; organisms of this genotype were also detected in the air of two rooms of the department where these postoperative infections occurred. In contrast, two environmental isolates from another building on the same campus showed a distinct genotype. Three cases of pulmonary infections, at a department which is located in proximity to the surgical department, were also caused by the endemic type, which suggests aerogenic spread of the endemic strain to these patients. Controls consisting of epidemiologically unrelated isolates from sporadic infections in other towns belonged in each case to a different genotype. PFGE was well suited to differentiate various types of N. farcinica and revealed an endemic strain causing postoperative wound infections possibly after aerogenic transmission.

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Citations

Jun 1, 2001·Current Infectious Disease Reports·Gio J. Baracco, Gordon M. Dickinson
Jul 11, 2006·Respiration; International Review of Thoracic Diseases·Marialuisa BocchinoCesare Saltini
Dec 18, 2013·PLoS Neglected Tropical Diseases·Paulo Victor Pereira BaioAna Luíza Mattos-Guaraldi
Apr 15, 2006·Clinical Microbiology Reviews·Barbara A Brown-ElliottRichard J Wallace
Sep 8, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Maria Bernadete F ChedidLuiz Carlos Severo
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N M Clark, UNKNOWN AST Infectious Diseases Community of Practice
Dec 23, 2015·Emerging Infectious Diseases·Maria ErcibengoaJosé Maria Marimón
May 17, 2008·Journal of Fish Diseases·Y ShimaharaT Yoshida
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N M ClarkUNKNOWN AST Infectious Diseases Community of Practice
Nov 17, 2020·Frontiers in Immunology·Rubén Martínez-Barricarte
Mar 1, 2019·Clinical Transplantation·Alejandro RestrepoUNKNOWN Infectious Diseases Community of Practice of the American Society of Transplantation
Mar 20, 2019·Pediatric Transplantation·Ratna AcharyaKiran Upadhyay
Jan 1, 2020·Infectious Disorders Drug Targets·Hossein Ali RahdarMohammad Mehdi Feizabadi

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