Tyrosinase and nestin immunohistochemical expression in melanocytic nevi as a histopathologic pattern to trace melanocyte differentiation and nevogenesis

Histochemistry and Cell Biology
Daniela MurtasMaria Teresa Perra

Abstract

While histological analysis represents a powerful tool for the classification of melanocytic lesions as benign or malignant, a clear-cut distinction between a nevus and a melanoma is sometimes a challenging step of the diagnostic process. The immunohistochemical detection of tyrosinase, cardinal melanogenic enzyme during melanocytic maturation, has often been helpful in formulating a differential diagnosis due to the peculiar staining pattern in nevocytes compared with melanoma cells. Tyrosinase distribution in nevi appears to overlap with the cytoarchitectural changes observable within these lesions, that result in epidermal or superficial dermal nevocytes being larger and strongly expressing melanocytic differentiation antigens, such as tyrosinase, compared with deeper dermal nevus cells. Our study aimed to evaluate the immunohistochemical expression pattern of tyrosinase in different histological types of acquired dysplastic melanocytic nevi, including junctional, compound, and intradermal nevi. Moreover, to estimate whether in nevocytes the expression of tyrosinase was associated with their differentiation state, we investigated the expression of two recognized markers of pluripotency, CD34 and nestin. In all examined nevi,...Continue Reading

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Aug 23, 2017·Histochemistry and Cell Biology·Daniela MurtasMaria Teresa Perra

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Citations

May 21, 2020·International Journal of Molecular Sciences·Kevin YangAndrzej T Slominski
Aug 28, 2019·International Journal of Molecular Sciences·Andrea DianaDaniela Murtas
Mar 19, 2020·Fish Physiology and Biochemistry·Minglin WuYangyang Jiang
Apr 10, 2020·Frontiers in Cell and Developmental Biology·Meriem BejaouiHiroko Isoda

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