PMID: 15388977Sep 25, 2004Paper

Tyrosinase inhibitor isolated from the leaves of Zanthoxylum piperitum

Bioscience, Biotechnology, and Biochemistry
Chang Ho Jeong, Ki Hwan Shim

Abstract

Two flavonols, quercetin (1) and quercitrin (2), were isolated from the leaves of Zanthoxylum piperitum. Their structures were established by UV, one- and two-dimensional NMR, and mass spectroscopic methods. Quercetin showed significant inhibition against mushroom tyrosinase with an IC50 value of 3.8 microg/ml, and appeared to inhibit the polyphenol oxidase activity of tyrosinase in a competitive manner (Ki = 10 +/- 0.20 microM) when L-tyrosine was used as a substrate, although it did not inhibit the melanin production of Streptomyces bikiniensis.

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Citations

Oct 26, 2005·Bioscience, Biotechnology, and Biochemistry·Te-Sheng ChangHang-Ching Lin
Dec 9, 2008·Bioscience, Biotechnology, and Biochemistry·Takayuki HanamuraHitoshi Aoki
Mar 2, 2006·Chemical & Pharmaceutical Bulletin·Sang Joon AhnSun Yeou Kima
Sep 2, 2006·Biological & Pharmaceutical Bulletin·Shaomin ZhongXuejun Zhu
Jul 9, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Y B RyuK H Park
Jul 15, 2006·Phytotherapy Research : PTR·Shoukat ParvezHyunsu Bae
Apr 11, 2013·Pharmaceutical Biology·Jin-Ming HwangErl-Shyh Kao
Sep 18, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Isao KuboKen-ichi Nihei
Oct 25, 2016·Pigment Cell & Melanoma Research·Monika B DolinskaYuri V Sergeev
May 12, 2019·Pigment Cell & Melanoma Research·Monika B DolinskaYuri V Sergeev
Oct 11, 2017·Journal of Food and Drug Analysis·Xueqin CuiNaisheng Bai
Jan 18, 2020·International Journal of Molecular Sciences·Monika B DolinskaYuri V Sergeev
Dec 24, 2008·Journal of Natural Products·Maya Mori-HongoToshio Miyase
Aug 8, 2021·International Journal of Molecular Sciences·Samuel A WachamoYuri V Sergeev
Aug 11, 2021·Plants·Antonella FaisFrancesca Pintus

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