Tyrosinase inhibitors and sesquiterpene diglycosides from Guioa villosa

Planta medica
Abdulmagid Alabdul MagidCatherine Lavaud

Abstract

Through a bioassay-guided phytochemical investigation involving mushroom tyrosinase inhibitory activity, seven farnesyl diglycosides ( 1 - 7), five flavonoids ( 8 - 12), one trimeric proanthocyanidin ( 13), two triterpenes ( 14 and 15), and one cerebroside ( 16), were isolated from the leaves of Caledonian Guioa villosa. Among them, crenulatosides E, F and G ( 1 - 3) were new acyclic sesquiterpene diglycosides. The sesquiterpene diglycosides isolated from the active EtOAc extract showed no inhibitory activity, whereas betulin ( 14), lupeol ( 15) and soyacerebroside I ( 16) demonstrated a potent tyrosinase inhibitory activity.

Citations

May 8, 2009·Biological & Pharmaceutical Bulletin·Takuji NakashimaKatsuhiko Ando
Jul 8, 2009·International Journal of Molecular Sciences·Te-Sheng Chang
Jan 8, 2010·International Journal of Molecular Sciences·Nico SmitStan Pavel
Feb 17, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Sang Yeul LeeTae-gyu Nam
Feb 27, 2013·Journal of Ethnopharmacology·Léocadie KamagajuPierre Duez
Aug 21, 2009·Natural Product Reports·Braulio M Fraga
Apr 17, 2008·Journal of Natural Products·Abdulmagid Alabdul MagidCatherine Lavaud

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