PMID: 337Dec 15, 1975

Tyrosine aminotransferase induction in normal and tumor-bearing chickens

International Journal of Cancer. Journal International Du Cancer
I HorváthA Gyuris

Abstract

Tyrosine aminotransferase (TAT) induction by glucagon and dexamethasone in the liver of tumor-bearing chickens was studied and compared with induction in healthy animals. The transplantable tumor was caused by inoculation of cells from a cell line induced by MC29 avian leukosis virus. TAT was hardly detectable in tumor tissue of control and dexamethasone-treated chickens, but it was induced by glucagon to levels which were significant although very low when compared to those in host liver or the liver of non-tumor-bearing controls after glucagon treatment. Dexamethasone failed to induce TAT in host liver at 8 A.M. while it significantly indiced TAT in the normal liver at the same time of the day. Similar failure of TAT induction was not detectable when glucagon was used instead of dexamethasone. Furthermore, it was found that diurnal variations in basal and dexamethasone or glucagon-induced TAT levels are considerably mitigated in host liver as compared to those observed in the liver of healthy animals. The possible reasons for these findings are discussed.

References

Jan 1, 1973·Advances in Enzyme Regulation·H A HopkinsV R Potter
Feb 4, 1974·Biochemical and Biophysical Research Communications·D E BushnellV R Potter
Aug 7, 1974·Biochimica Et Biophysica Acta·J J OhisaloJ P Pispa
Apr 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·I B Black, J Axelrod
Apr 1, 1966·Developmental Biology·W E Knox, H M Eppenberger

Citations

Oct 1, 1980·Journal of Steroid Biochemistry·P Arányi, V Quiroga
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·I O Onoagbe, A J Dickson
Nov 1, 1994·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·I O OnoagbeA J Dickson
Mar 1, 1979·Journal of Toxicology and Environmental Health·I Földes

Related Concepts

Rous-Associated Virus
Circadian Rhythms
Oradexon
Enzyme Induction
Glucagon
Liver
Neoplasm Transplantation
Neoplasms, Experimental
Transplantation, Homologous
Tyrosine Aminotransferase

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