Tyrosine and phenylalanine restriction induces G0/G1 cell cycle arrest in murine melanoma in vitro and in vivo

Nutrition and Cancer
Y M FuG G Meadows

Abstract

Tyr-Phe and Met limitation in vitro inhibited cell proliferation and proliferating cell nuclear antigen (PCNA) expression to a greater extent than serum limitation. Tyr-Phe and serum limitation arrested cells in the G0/G1 phase; Met limitation blocked cells in the G0/G1 and S phases. Tyr-Phe limitation progressively decreased cyclin D1 expression to 30% of control within four days and did not affect expression of cyclin D3 or cyclin-dependent kinase (CDK2, CDK4, and CDK5) expression, Met limitation decreased cyclin D3 expression to 25% of control and CDK2 expression to 32% of control by Day 4 and did not affect expression of cyclin D1, CDK4, and CDK5. Serum limitation inhibited cyclin D1 and cyclin D3 expression to 24% of control after four days and did not effect CDK expression. Expression of two CDK inhibitors, p21WAF1/Cip1 and p27Kip1, was not changed by amino acid or serum limitation. Dietary restriction of Tyr-Phe in mice bearing subcutaneous B16BL6 melanoma tumors decreased tumor growth rate compared with mice fed a normal diet. Tumors from Tyr-Phe-restricted mice exhibited decreased PCNA expression, G0/G1 phase cell cycle arrest, and reduced cyclin D1 expression. These data indicate that decreased tumor growth in vivo as...Continue Reading

References

Sep 1, 1990·Clinical & Experimental Metastasis·C A ElstadR M Abdallah
Apr 2, 1987·Nature·R BravoH Macdonald-Bravo
Jul 15, 1986·International Journal of Cancer. Journal International Du Cancer·T J McMillanI R Hart
Oct 9, 1995·International Journal of Cancer. Journal International Du Cancer·T IwasakiH Akedo
Nov 18, 1994·Cell·C J Sherr
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S BiroS E Epstein

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Citations

Aug 17, 2004·European Journal of Nutrition·Mar LarrosaJuan Carlos Espín
May 25, 2002·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·Michelle N HarvieN Thatcher
Sep 3, 2014·International Journal of Genomics·Ayla Valinezhad OrangMina Kazemzadeh-Bavili
Feb 26, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Thiago Antonio FedeleDurvanei Augusto Maria
Aug 4, 2012·International Journal of Cancer. Journal International Du Cancer·Gyula KulcsárTamás Czömpöly
Mar 9, 2017·Nature Reviews. Gastroenterology & Hepatology·James L AlexanderJames M Kinross
Jun 5, 2004·Melanoma Research·Binglan Yu, Thomas Ming Swi Chang
Jun 13, 2012·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ming CaoDonghai Lin
May 16, 2020·Cancer & Metabolism·Krishnadev OrugantySriram Chandrasekaran
Oct 18, 2001·Journal of the American College of Nutrition·D M Klurfeld
May 22, 2007·The Journal of Nutrition·Ya-Min Fu, Gary G Meadows
Oct 19, 2019·Plant Science : an International Journal of Experimental Plant Biology·Mark C Perkowski, Katherine M Warpeha
Aug 9, 2021·European Journal of Medicinal Chemistry·Jin LiGuan Wang
Jan 4, 2019·ACS Applied Materials & Interfaces·Maria Godoy-GallardoLeticia Hosta-Rigau

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