Tyrosine availability modulates potassium-induced striatal catecholamine efflux in vivo

Brain Research
George E JaskiwRodolfo Bongiovanni

Abstract

The relationship between tyrosine availability and high potassium (K+) induced dopamine (DA) and norepinephrine (NE) efflux was examined in striatum using in vivo microdialysis. High K+ (80 mM) was included in perfusate for two 30 min periods, 2.5 h apart. After the first high-K+ perfusion, a tyrosine- and phenylalanine-free mixture of large neutral amino acids (LNAA(-)) was administered (IP) to lower brain tyrosine. Tyrosine (0, 25, 50 or 100 mg/kg IP) was administered 30 min prior to the second high-K+ perfusion. The ratio of catecholamine efflux during the two perfusions (P2/P1) was compared between groups. LNAA(-) significantly lowered P2/P1 for both DA and NE. Tyrosine 25-50 mg/kg blocked the LNAA(-) effect. We conclude that catecholamine efflux during prolonged depolarization is tyrosine dependent. Analyses of LNAA levels suggest that availability of tyrosine for tyrosine hydroxylation may be modulated by competition between LNAAs within brain extracellular fluid.

References

Jun 1, 1978·Journal of Neurochemistry·J D Fernstrom, D V Faller
Jul 1, 1992·Neurochemistry International·E EdwardsF A Henn
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·B K LipskaD R Weinberger
Jan 1, 1990·Neuroscience·F ValtortaB Ceccarelli
May 1, 1989·Journal of Neurochemistry·M J DuringR J Wurtman
Mar 15, 1986·Biochemical Pharmacology·J D Milner, R J Wurtman
May 28, 1986·Biochimica Et Biophysica Acta·F J Diez-GuerraC Giménez
Jul 1, 1974·Journal of Neurochemistry·R L Patrick, J D Barchas
Sep 1, 1972·British Journal of Pharmacology·G Bustos, R H Roth
Jan 1, 1983·Journal of Neural Transmission·N E AndénB Liljenberg
Jul 1, 1983·Physiological Reviews·S L FooteG Aston-Jones
Jun 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J E Cremer, M P Seville
Sep 7, 1981·Biochimica Et Biophysica Acta·M C AragónF Valdivieso
Oct 1, 1981·Journal of Neurochemistry·D P West, M Fillenz

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Citations

Oct 4, 2011·Brain Research·Hewlet G McFarlaneGeorge E Jaskiw
Jul 9, 2008·European Journal of Pharmacology·George E JaskiwRodolfo Bongiovanni
Sep 21, 2013·Schizophrenia Research·Rodolfo BongiovanniGeorge E Jaskiw
Apr 15, 2019·International Journal of Developmental Disabilities·Vidya NikamMohan Kulkarni

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