PMID: 3214752Sep 1, 1988Paper

Tyrosine: effects on catecholamine release

Brain Research Bulletin
I N AcworthR J Wurtman

Abstract

Tyrosine administration elevates striatal levels of dopamine metabolites in animals given treatments that accelerate nigrostriatal firing, but not in untreated rats. We examined the possibility that the amino acid might actually enhance dopamine release in untreated animals, but that the technique of measuring striatal dopamine metabolism was too insensitive to demonstrate such an effect. Dopamine release was assessed directly, using brain microdialysis of striatal extracellular fluid. Tyrosine administration (50-200 mg/kg IP) did indeed cause a dose related increase in extracellular fluid dopamine levels with minor elevations in levels of DOPAC and HVA, its major metabolites, which were not dose-related. The rise in dopamine was short-lived, suggesting that receptor-mediated feedback mechanisms responded to the increased dopamine release by diminishing neuronal firing or sensitivity to tyrosine. These observations indicate that measurement of changes in striatal DOPAC and HVA, if negative, need not rule out increases in nigrostriatal dopamine release.

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Citations

Jan 1, 1992·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·S KaakkolaP T Männistö
Jul 1, 1991·Pharmacology, Biochemistry, and Behavior·A LevyH R Lieberman
Mar 1, 1990·Trends in Pharmacological Sciences·G Di Chiara
Jul 1, 1991·Brain Research Bulletin·A LevyT M Rauch
Jan 1, 1993·Brain Research Bulletin·M J StillmanH R Lieberman
Mar 29, 2001·Physiology & Behavior·S K YeghiayanH R Lieberman
Nov 10, 2011·Brain : a Journal of Neurology·Mai-Anh T NguyenEdna C Hardeman
Jun 6, 2013·Journal of Psychiatry & Neuroscience : JPN·Elizabeth I CawleyMarco Leyton
Sep 27, 2014·Psychological Research·Lorenza S ColzatoBernhard Hommel
Jul 25, 2014·Neuropsychologia·Lorenza S ColzatoBernhard Hommel
Jan 18, 2014·Neuropsychologia·Lorenza S ColzatoBernhard Hommel
Jan 16, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lei WangRichard J Wurtman
Jun 14, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sabrina StrangSoyoung Q Park
Mar 8, 1990·Journal of Theoretical Biology·A Slominski, R Paus
Aug 29, 2009·Brain Research Bulletin·Yusuke KabukiMitsuhiro Furuse

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