Tyrosine hydroxylase regulation in adult rat striatum following short-term neonatal exposure to manganese

Metallomics : Integrated Biometal Science
Tanara V PeresRodrigo B Leal

Abstract

Manganese (Mn) is an essential trace element required for a range of physiological processes, but Mn can also be neurotoxic especially during development. Excess levels of Mn accumulate preferentially in the striatum and can induce a syndrome called manganism, characterized by an initial stage of psychiatric disorder followed by motor impairment. In the present study, we investigated the effects of Mn exposure on the developing dopaminergic system, specifically tyrosine hydroxylase (TH) protein and phosphorylation levels in the striatum of rats. Neonatal rats were exposed to Mn intraperitoneally (ip) from post-natal day 8 up to day 12 (PND8-12). Striatal tissue was analysed on PND14 or PND70, to detect either short-term or long-term effects induced by Mn exposure. There was a dose dependent increase in TH protein levels in the striatum at PND14, reaching significance at 20 mg kg(-1) Mn, and this correlated with an increase in TH phosphorylation at serines 40, 31 and 19. However, in the striatum at PND70, a time by which Mn levels were no longer elevated, there was a dose dependent decrease in TH protein levels, reaching significance at 20 mg kg(-1) Mn, and this correlated with TH phosphorylation at Ser40 and Ser19. There was ho...Continue Reading

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Citations

Jun 5, 2016·Metallomics : Integrated Biometal Science·Rachel Narehood AustinTomás R Guilarte
Mar 16, 2017·Biomaterials Science·Xinyu LiXizeng Feng
Feb 5, 2019·Journal of Neurochemistry·Peter R Dunkley, Phillip W Dickson
Jul 22, 2017·Neurotoxicity Research·Mayuko Y KumasakaMasashi Kato
May 1, 2021·International Journal of Molecular Sciences·Alexey A TinkovMichael Aschner

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