PMID: 7543244Jul 1, 1995Paper

Tyrosine kinase activation is necessary for inducible nitric oxide synthase expression by interleukin-1 beta

The American Journal of Physiology
T Tetsuka, A R Morrison

Abstract

The inflammatory cytokine interleukin-1 (IL-1) induces the inducible form of nitric oxide synthase (iNOS) with an increase in nitric oxide in rat mesangial cells. However, the cellular mechanisms that underlie the induction of iNOS by IL-1 beta in mesangial cells has not been clarified. Because we have shown that tyrosine kinase inhibitors attenuate IL-1 beta-induced cyclooxygenase expression and prostaglandin production, we investigated the effect of tyrosine kinase inhibitors on IL-1 beta-induced nitrite production and iNOS mRNA expression in rat mesangial cells. The tyrosine kinase inhibitors genistein and herbimycin A attenuated IL-1 beta-induced nitrite production in a dose-dependent manner. In addition, both of these inhibitors blocked IL-1 beta-induced iNOS mRNA expression. These data suggest that tyrosine kinase(s) plays a central role in IL-1 beta signaling to induce iNOS in rat mesangial cells.

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Citations

Jan 22, 2000·The Journal of Clinical Investigation·T L PalloneA S Verkman
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·S A Kharitonov, P J Barnes
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martin H DeiningerHermann J Schluesener
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·S A KharitonovK F Chung
Oct 5, 2002·Hypertension·Erik P SilldorffThomas L Pallone
Sep 24, 2009·Molecular Nutrition & Food Research·Alicja MortensenGerhard Sontag
Jul 27, 2006·Journal of Neurotrauma·Martin H DeiningerHermann J Schluesener
Mar 12, 1999·Journal of the American Society of Nephrology : JASN·J M Sands

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