Tyrosine kinase expression in pediatric high grade astrocytoma

Journal of Neuro-oncology
Muh-Lii LiangCynthia Hawkins

Abstract

The over-expression of several receptor tyrosine kinases in adult high grade astrocytomas (HGA) led to trials of tyrosine kinase inhibitors in these patients. Similar molecular genetic analysis of pediatric HGA is only beginning to be published. Thus it is unclear to what degree these pathways are also involved in the pediatric age group and whether they may also serve as useful therapeutic targets for children with HGAs. Here we investigated the protein expression profile of a series of pediatric HGAs. Following institutional ethical approval, clinical information and tumor samples were obtained for 42 HGA patients. Mean age at presentation was 10.1 years (range 0.13-19.3 years). OS was 12% and PFS was 3.7%. Extent of resection was associated with improved PFS (P = 0.0015) with a trend towards improved OS (P = 0.08). There was no significant effect of age or adjuvant therapy use on PFS or OS. Immunopositivity for each of the markers was as follows: p53 35%; PDGFR-alpha 45%; PDGFR-beta 31%; PTEN 67%; EGFR wild type 58%; EGFRvIII 2%. No significant effect on OS or PFS was found for any of the markers by log rank analysis. However, all long-term survivors expressed PTEN and were EGFRvIII negative. Further, there were distinct dif...Continue Reading

References

Dec 1, 1994·The New England Journal of Medicine·I F Pollack
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H S NicholsonG H Reaman
Jun 28, 2000·Cancer·P Kleihues, L H Sobin
Jan 5, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·R L CampD L Rimm
Feb 8, 2002·The New England Journal of Medicine·Ian F PollackUNKNOWN Children's Cancer Group
Sep 10, 2003·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·M A IdoateF J Pardo-Mindán
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amy B HeimbergerKenneth Aldape
Oct 21, 2005·Journal of Translational Medicine·Amy B HeimbergerKenneth Aldape
Nov 12, 2005·The New England Journal of Medicine·Ingo K MellinghoffPaul S Mischel

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Citations

Apr 10, 2012·Brain Tumor Pathology·Hidehiro OkaKiyotaka Fujii
Jul 26, 2011·Neuro-oncology·T J MacDonaldC M Kramm
Jan 13, 2012·Current Oncology Reports·Amulya A Nageswara Rao, Roger J Packer
May 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Emmanuelle HuillardDavid H Rowitch
Jan 19, 2013·Paediatric Drugs·Trent R HummelDavid Franz
Feb 27, 2013·Current Treatment Options in Neurology·Jane E Minturn, Michael J Fisher
Nov 12, 2009·Future Oncology·Catherine LamUte Bartels
Jan 18, 2012·Current Neurology and Neuroscience Reports·Roger J Packer
Mar 3, 2012·Journal of Neuro-oncology·Roberto Jose DiazJames T Rutka
Dec 12, 2017·Clinical Pharmacology and Therapeutics·Shivam Kamlesh PatelGregory Reaman
Sep 10, 2009·Annual Review of Pathology·Candece L GladsonWei Michael Liu
Dec 3, 2014·CNS Oncology·Omar Chamdine, Amar Gajjar
May 30, 2012·Nature Reviews. Clinical Oncology·Chris JonesDarren Hargrave
Mar 31, 2017·Journal of Neuro-oncology·Steve BraunsteinDaphne Haas-Kogan
Jun 27, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sirintip BoonjaraspinyoNarong Khuntikeo
Sep 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dorine A BaxChris Jones
May 9, 2021·Journal for Immunotherapy of Cancer·Claudia Manuela ArnoneFrancesca Del Bufalo
Jul 23, 2011·Parasitology International·Sirintip BoonjaraspinyoVajarabhongsa Bhudhisawasdi

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