Tyrosine kinase inhibitors and pregnancy in chronic myeloid leukemia: opinion, evidence, and recommendations.

Therapeutic Advances in Hematology
Elisabetta AbruzzeseEkaterina Chelysheva

Abstract

With survival expectation that of age-matched controls and given excellent response and worldwide access to tyrosine kinase inhibitors (TKI), family planning is increasingly important for a considerable fraction of patients with chronic myeloid leukemia (CML). The potential for therapy discontinuation ("treatment free remission") can afford the opportunity for a CML patient in deep response to plan and carry a pregnancy to full term without any therapeutic interventions. However, the reality of pregnancy desired or occurring when patients are not eligible for treatment-free remission raises the discussion of therapy choices during pregnancy. To date there are no official guidelines available to assist patients and clinicians with these decisions. This first position paper aims to analyze information published and presented surrounding this challenging area, with focus on different scenarios of disease burden and time from CML diagnosis, including CML discovered during pregnancy and pregnancy during CML treatment. An updated review, supported by data and presented together with authors' joint recommendations, is aimed to counsel the practical management of CML patients and pregnancy.

References

Mar 23, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·M A RussellM J Egorin
Mar 7, 2008·Blood·Seonaid M PyeJane F Apperley
Dec 17, 2008·Archives of Gynecology and Obstetrics·Ridvan AliAhmet Tunali
Dec 5, 2009·Best Practice & Research. Clinical Haematology·Jane Apperley
Dec 28, 2011·Reproductive Toxicology·P Yazdani BrojeniG Koren
May 8, 2014·Mediterranean Journal of Hematology and Infectious Diseases·Elisabetta AbruzzesePaolo De Fabritiis
Mar 31, 2015·Annals of Hematology·Bradley Chereda, Junia V Melo
Apr 9, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C JoveletS Gil
Sep 9, 2015·American Journal of Hematology·Jorge E CortesJane F Apperley
Jun 30, 2016·Expert Review of Hematology·Elisabetta AbruzzeseMichele Baccarani
Apr 4, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Leonardo CampiottiAlessandro Squizzato
Apr 7, 2017·Obstetrics and Gynecology·Richard M BurwickBrian J Druker
Jul 10, 2017·International Journal of Hematology·Delphine Rea, Jean-Michel Cayuela
Jul 14, 2017·Leukemia & Lymphoma·Ekaterina ChelyshevaGhermes Chilov
May 15, 2018·Mediterranean Journal of Hematology and Infectious Diseases·Ekaterina ChelyshevaAnna Turkina
Aug 8, 2018·Expert Review of Hematology·Martin GriesshammerKai Wille
Sep 1, 2018·The Lancet Child & Adolescent Health·Tineke VandenbrouckeFrédéric Amant
Sep 6, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Jerald P RadichHema Sundar
Nov 8, 2018·European Journal of Haematology·Elisabetta AbruzzeseMichael J Mauro
Jan 24, 2019·European Journal of Haematology·Ekaterina Chelysheva, Anna Turkina
Jul 17, 2019·Mediterranean Journal of Hematology and Infectious Diseases·Dipty JainPooja Lodha
Jul 1, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A HochhausUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Oct 3, 2020·International Journal of Hematologic Oncology·Jorge E CortesTim H Brümmendorf

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
leukapheresis
pregnancy test

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.