Tyrosine Kinase Receptors in Oncology

International Journal of Molecular Sciences
Jorge Esteban-VillarrubiaJavier Molina-Cerrillo

Abstract

Tyrosine kinase receptors (TKR) comprise more than 60 molecules that play an essential role in the molecular pathways, leading to cell survival and differentiation. Consequently, genetic alterations of TKRs may lead to tumorigenesis and, therefore, cancer development. The discovery and improvement of tyrosine kinase inhibitors (TKI) against TKRs have entailed an important step in the knowledge-expansion of tumor physiopathology as well as an improvement in the cancer treatment based on molecular alterations over many tumor types. The purpose of this review is to provide a comprehensive review of the different families of TKRs and their role in the expansion of tumor cells and how TKIs can stop these pathways to tumorigenesis, in combination or not with other therapies. The increasing growth of this landscape is driving us to strengthen the development of precision oncology with clinical trials based on molecular-based therapy over a histology-based one, with promising preliminary results.

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Citations

Mar 7, 2021·International Journal of Molecular Sciences·Eva SchallerMichael Höpfner
Jun 3, 2021·International Journal of Molecular Sciences·Elena FerrariSaverio Bettuzzi
Nov 3, 2021·Bioscience Reports·Olga Villamar-CruzIgnacio Camacho-Arroyo

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Methods Mentioned

BETA
GTPase
ubiquitination
nucleotide exchange
GTPases
nuclear translocation
transfection
biopsies
genotyping

Clinical Trials Mentioned

NCT01827384

Software Mentioned

SATURN
OPTIMAL
EURTAC
INVICTUS
NAVIGATOR
ENSURE

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