PMID: 9552386Jan 1, 1996Paper

Tyrosine kinases wee1 and mik1 as effectors of DNA replication checkpoint control

Progress in Cell Cycle Research
J Tourret, F McKeon

Abstract

Cell cycle studies have revealed mechanisms that prevent cell division if DNA fails to be completely replicated or sustains damage. Here we focus on the evidence from yeast genetics that the wee1 and mik1 tyrosine kinases cooperate in the inhibitory phosphorylation of cdc2p, and the possibility that these kinases function in pathways that ensure the integrity of the genome prior to cell division. We also review the progress in cloning and analysing wee1-like tyrosine kinases from higher eukaryotes, and the evidence for and against their functioning in ensuring DNA replication prior to mitosis. Finally, we discuss the genes involved in these feedback controls and suggest that wee1p and mik1p might be the ultimate effectors that prevent mitosis when a checkpoint is triggered.

Citations

Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·A SveiczerB Novak
Oct 1, 2011·Molecular & Cellular Proteomics : MCP·Zhixiang WuBernhard Kuster
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·M D Mendenhall, A E Hodge
Nov 16, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Giovanna Damia, Massimo Broggini
Jul 16, 2014·BMC Genomics·Adrijana ŠkugorØivind Andersen

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