Tyrosine phosphorylation-dependence of caveolae-mediated endocytosis.

Journal of Cellular and Molecular Medicine
Maria SverdlovRichard D Minshall

Abstract

Caveolae are flask-shaped plasma membrane invaginations that mediate endocytosis and transcytosis of plasma macromolecules, such as albumin, insulin and low-density lipoprotein (LDL), as well as certain viruses, bacteria and bacterial toxins. Caveolae-mediated transcytosis of macromolecules is critical for maintaining vascular homeostasis by regulating the oncotic pressure gradient and tissue delivery of drugs, vitamins, lipids and ions. Entrapment of cargo within caveolae induces activation of signalling cascades leading to caveolae fission and internalization. Activation of Src tyrosine kinase is an early and essential step that triggers detachment of loaded caveolae from the plasma membrane. In this review, we examine how Src-mediated phosphorylation regulates caveolae-mediated transport by orchestrating the localization and activity of essential proteins of the endocytic machinery to regulate caveolae formation and fission.

References

May 1, 1992·The Journal of Cell Biology·L Ghitescu, M Bendayan
Feb 21, 1992·Cell·K G RothbergR G Anderson
Dec 1, 1987·The Journal of Cell Biology·A J MiliciG E Palade
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E SchnitzerG E Palade
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·A M FraR G Parton
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·M SargiacomoM P Lisanti
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·A J KoleskeM P Lisanti
Dec 1, 1994·The Journal of Cell Biology·R G PartonK Simons
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·D PredescuG E Palade
Jan 2, 1996·FEBS Letters·M Way, R G Parton
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·P E SchererM P Lisanti
Feb 1, 1997·The American Journal of Physiology·S A PredescuG E Palade
Jun 27, 1997·The Journal of Biological Chemistry·J A EngelmanM P Lisanti
Nov 5, 1997·The Journal of Biological Chemistry·C TiruppathiA B Malik
May 16, 1998·The Journal of Cell Biology·J R HenleyM A McNiven
Oct 6, 1998·Annual Review of Biochemistry·R G Anderson
Apr 10, 1999·Molecular Biology of the Cell·R Nomura, T Fujimoto
Dec 10, 1999·Experimental Cell Research·T AokiT Fujimoto
Jan 12, 2000·The Journal of Cell Biology·T MachleidtR G Anderson
Apr 11, 2001·Molecular Biology of the Cell·S A PredescuG E Palade
Jul 18, 2001·The Journal of Biological Chemistry·B RazaniM P Lisanti
Nov 2, 2001·The Journal of Biological Chemistry·W SchubertM P Lisanti
Nov 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·S M VogelA B Malik

❮ Previous
Next ❯

Citations

Apr 8, 2009·Pathology Oncology Research : POR·A Saleh YounesGyörgy Berencsi
Jun 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zachary S Morris, Andrea I McClatchey
Dec 31, 2008·Antioxidants & Redox Signaling·Nihal S ParkarRichard D Minshall
Feb 8, 2011·Antioxidants & Redox Signaling·Si JinPin-Lan Li
Aug 22, 2008·Molecular Biology of the Cell·Bingbing WuDaniel M Suter
Sep 18, 2009·Molecular Biology of the Cell·Maria SverdlovRichard D Minshall
Jan 7, 2011·Molecular Biology of the Cell·Elisabeth T BarfodSteven D Lidofsky
Dec 17, 2008·Current Opinion in Nephrology and Hypertension·Paul A Insel, Hemal H Patel
Sep 13, 2012·International Journal of Alzheimer's Disease·Kristen E Funk, Jeff Kuret
May 23, 2009·Journal of Cell Science·Carsten G Hansen, Benjamin J Nichols
Mar 5, 2009·Journal of Cell Science·Kirsi RientoBenjamin J Nichols
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas M CoatePhilip F Copenhaver
Feb 14, 2014·Cancer Metastasis Reviews·Andreas VarkarisPaul G Corn
Nov 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luis TecedorBeverly L Davidson
Feb 16, 2010·Trends in Cell Biology·Carsten G Hansen, Ben J Nichols
May 29, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nino MuradashviliDavid Lominadze
Jan 13, 2015·Advanced Drug Delivery Reviews·Prarthana V RewatkarMarie-Odile Parat
Nov 26, 2008·Microvascular Research·Guochang Hu, Richard D Minshall
Oct 2, 2009·Journal of Neuroscience Research·Matthias SchmitzHans H Althaus
Dec 24, 2010·The Biochemical Journal·Dolores D Mruk, C Yan Cheng
Feb 3, 2015·Expert Opinion on Therapeutic Targets·Lili XuXinfeng Liu
May 9, 2012·Prion·Garth F Hall, Brian A Patuto
May 5, 2009·Biochimica Et Biophysica Acta·Denis Gingras, Richard Béliveau
May 14, 2016·Molecular Biology of the Cell·Adriana M ZimnickaRichard D Minshall
Apr 10, 2010·Journal of Applied Oral Science : Revista FOB·Lucyene MiguitaVera Cavalcanti de Araújo
Jul 18, 2018·The Journal of Physiology·Szandor SimmonsWolfgang M Kuebler
Aug 10, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Anandika DhaliwalTatiana Segura
Jan 30, 2019·Expert Opinion on Drug Delivery·Lin-Yan WanJiang-Feng Wu
Sep 6, 2015·The European Respiratory Journal·Olivier BoucheratSébastien Bonnet
Mar 30, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Hyehun ChoiFred S Lamb

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Methods Mentioned

BETA
electron microscopy
GTPase

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