PMID: 7514299May 10, 1994Paper

Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells

Proceedings of the National Academy of Sciences of the United States of America
Y AokiS Pillai

Abstract

Proteins that bind to discrete domains of the Blk, Fyn, Lyn, and Btk protein tyrosine kinases were examined in pre-B cells that had not been subjected to any external stimulation, as well as in nonstimulated and antigen-receptor-ligated B cells. Proteins that bind to the Src homology 2 domains of Blk and Fyn were identified in B cells that had been activated with anti-IgM but were not identified in unstimulated B cells. A number of Blk and Fyn Src homology 2 domain-binding phosphoproteins were also observed in pre-B cells that had not been stimulated in vitro. The phosphoproteins seen in activated B cells potentially represent substrates that play a role in the pathway of antigen-receptor-mediated signaling. Distinct signaling pathways involving distinguishable kinase substrates may be relevant in pre-B-cell-receptor-mediated cell survival during ontogeny. These results indirectly support models that predict constitutive ligand-independent signaling by the pre-antigen receptor during lymphoid ontogeny.

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Citations

Feb 6, 2002·Springer Seminars in Immunopathology·E M Fuentes-Pananá, J G Monroe
Apr 1, 1997·Immunology and Cell Biology·H KarasuyamaK Kuida
Sep 7, 2011·Immunology and Cell Biology·Elizabeth M SamuelsonSandra M Hayes
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y AokiS Pillai
Feb 1, 1996·The Journal of Experimental Medicine·K LassouedM D Cooper
Aug 1, 1997·Leukemia & Lymphoma·A Von KnethenH Tesch
Nov 29, 2011·Current Opinion in Immunology·Shiv PillaiAnnaiah Cariappa
Nov 18, 1997·Home Care Provider·M Sweeney
Jun 4, 2011·Expert Opinion on Therapeutic Targets·Rudi W HendriksFrank Jt Staal
Sep 1, 1995·Immunity·W N KhanL A Herzenberg
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P Hasler, M Zouali
Jun 30, 1995·The Journal of Biological Chemistry·Y AokiS Pillai
Oct 3, 2000·The Journal of Biological Chemistry·H Y JuiH M Shih
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ezequiel M Fuentes-PananáJohn G Monroe
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ezequiel M Fuentes-PananáJohn G Monroe
Feb 14, 2004·Immunological Reviews·Shiv PillaiStewart T Moran

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