PMID: 7015948May 1, 1981Paper

U-500 insulin in the treatment of antibody-mediated insulin resistance

Annals of Internal Medicine
D M NathanD B Carr

Abstract

Three patients with antibody-mediated insulin resistance were treated with U-500 regular insulin subcutaneously. Insulin requirements decreased dramatically (55% to 75%) when therapy was changed from U-100 NPH pork to equivalent doses of U-500 regular pork insulin. There was no difference in antibody affinity for the insulin in these two preparations as shown by competition experiments. These observations demonstrate that U-500 insulin is a useful alternative in the treatment of antibody-mediated insulin resistance. The mechanism for this effect is yet to be determined.

Citations

Mar 1, 2011·Pediatric Diabetes·Georgeanna J Klingensmith
Dec 1, 1992·Diabetes Research and Clinical Practice·M TominagaH Sasaki
Jun 1, 1988·Diabetes/metabolism Reviews·D S Schade
Nov 17, 2006·Diabetes/metabolism Research and Reviews·R GargI G Lawrence
Sep 6, 2007·Endocrine Reviews·S Edwin FinebergAlan S Krasner
May 13, 2020·Endocrine Reviews·Irl B HirschEugene E Wright
Jan 16, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Deepti G BulchandaniMitchell S Hamburg
Jan 1, 1987·The Diabetes Educator·J A Fain

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