PMID: 8444012Mar 1, 1993Paper

U-77,863: a novel cinnanamide isolated from Streptomyces griseoluteus that inhibits cancer invasion and metastasis

Clinical & Experimental Metastasis
D R WelchK H Yohem

Abstract

Several cinnamoyl compounds have been shown to have antitumor activities, but not specifically anti-invasive or antimetastatic effects. U-77,863 (o-methyl cinnanamide) was originally isolated from a fermentation beer of Streptomyces griseoluteus and recently synthesized (Harper, DE and Welch DR. Journal of Antibiotics, in press). Based upon some differential activities of cinnanamides, in general, and U-77,863, specifically, we tested the hypothesis that U-77,863 could inhibit invasion and metastasis of human malignant melanoma cell lines C8161 and A375M. Pretreatment of melanoma cells in vitro with nontoxic doses of U-77,863 caused a dose-, and time-dependent, reversible reduction (IC50 = 12.5 micrograms/ml) of invasion through Matrigel-coated polycarbonate filters in the Membrane Invasion Culture System (MICS). Likewise, lung colonization was significantly (P < 0.05) inhibited when tumor cells were pretreated in vitro with U-77,863 prior to intravenous injection. Structure-activity analysis revealed that the acrylamide side-chain alone and cinnanamide were only slightly less potent than U-77,863, whereas cinnamic acid analogs did not inhibit tumor cell invasion at doses < or = 100 micrograms/ml. U-77,863 inhibits invasion and...Continue Reading

References

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Dec 1, 1991·Pigment Cell Research·K H YohemD R Welch
Jan 21, 1991·International Journal of Cancer. Journal International Du Cancer·D R WelchM J Hendrix
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Aug 1, 1990·The Journal of Antibiotics·H KameiT Oki
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D R WelchM Nakajima
Aug 31, 1987·Biochemical and Biophysical Research Communications·T ShiraishiK Watanabe
Mar 15, 1989·International Journal of Cancer. Journal International Du Cancer·D R WelchM J Hendrix
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Jan 1, 1983·Cancer Metastasis Reviews·M M Mareel
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