U2AF1 mutations alter splice site recognition in hematological malignancies

doi:10.1101/001107

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U2AF1 mutations alter splice site recognition in hematological malignancies

bioRxiv

Dec 3, 2013

Janine O IlaganRobert K Bradley

PMID: 990001107

DOI: 10.1101/001107

Abstract

Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies; however, the molecular consequences of these mutations are unknown. Here, we synthesize patient data, cell culture experiments...read more

Mentioned in this Paper

DNMT3B

U2AF1

Zinc Fingers

In Vivo

Pathogenic Aspects

Biochemical Pathway

DNA Methylation [PE]

Pathogenesis

Hematologic Neoplasms

Genes

Paper Details

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