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U2AF1 mutations alter splice site recognition in hematological malignancies

bioRxiv

Dec 3, 2013

Janine O IlaganRobert K Bradley

Abstract

Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies; however, the molecular consequences of these mutations are unknown. Here, we synthesize patient data, cell culture experiments...read more

Mentioned in this Paper

DNMT3B
U2AF1
Zinc Fingers
In Vivo
Pathogenic Aspects
Biochemical Pathway
DNA Methylation [PE]
Pathogenesis
Hematologic Neoplasms
Genes
8
9
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U2AF1 mutations alter splice site recognition in hematological malignancies

bioRxiv

Dec 3, 2013

Janine O IlaganRobert K Bradley

PMID: 990001107

DOI: 10.1101/001107

Abstract

Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies; however, the molecular consequences of these mutations are unknown. Here, we synthesize patient data, cell culture experiments...read more

Mentioned in this Paper

DNMT3B
U2AF1
Zinc Fingers
In Vivo
Pathogenic Aspects
Biochemical Pathway
DNA Methylation [PE]
Pathogenesis
Hematologic Neoplasms
Genes
8
9

Similar Papers Found In These Feeds

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