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U2AF1 mutations alter splice site recognition in hematological malignancies

bioRxiv

Dec 3, 2013

Janine O IlaganRobert K. Bradley

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Abstract

Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies. Here, we sought to determine how mutations affecting the 3' splice site recognition factor U2AF1 alter its normal role in RNA ...read more

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  • U2AF1 mutations alter splice site recognition in hematological malignancies

    bioRxiv

    Dec 3, 2013

    Janine O IlaganRobert K. Bradley

    PMID: 990001107

    DOI: 10.1101/001107

    Abstract

    Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies. Here, we sought to determine how mutations affecting the 3' splice site recognition factor U2AF1 alter its normal role in RNA ...read more

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