U3 snoRNA promoter reflects the RNA's function in ribosome biogenesis.

Current Genetics
Sadeq Nabavi, Ross N Nazar

Abstract

An efficiently expressed "tagged" gene system was used to study promoter sequence elements in genes encoding the U3 snoRNAs of Schizosaccharomyces pombe. Transcription was found dependent on two previously thought, mutually exclusive elements, a TATA-box, as found in other S. pombe snRNA gene promoters, and a Homol D-box, often considered a TATA-box analogue in the promoters of genes that encode ribosomal proteins. The Homol D-box is critical while the TATA-box strongly influences transcription efficiency but is not essential. The results suggest that the U3 snoRNA promoter may represent the fusion of two promoter systems reflecting the special role of this RNA in ribosome biogenesis. Steady state measurements of cellular RNAs support such a coordinated regulation of the U3 snoRNA.

References

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May 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Amos TanayRon Shamir
Aug 3, 2005·Analytical Biochemistry·Sadeq Nabavi, Ross N Nazar
Jun 5, 2008·The Journal of Biological Chemistry·Sadeq NabaviRoss N Nazar

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Citations

Jan 5, 2017·Non-coding RNA·Sebastian CanzlerJana Hertel
Jun 3, 2021·Non-coding RNA·Laeya BaldiniStéphane Labialle
May 19, 2009·Genomics·Giorgio DieciBarbara Montanini

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