U500 regular insulin use in insulin-resistant type 2 diabetic veteran patients.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Anne E ZiesmerFredrick L Dunn

Abstract

To evaluate the use of U500 regular insulin therapy in insulin-resistant patients with type 2 diabetes mellitus who were previously treated with high-dosage U100 insulin regimens. At a large Veterans Affairs medical center, a retrospective chart review was performed of all patients whose U100 insulin regimens were converted to U500 regular insulin regimens using a protocol to ensure patient safety. Patients were followed up for longer than 6 months. Data reviewed included total daily dosage of insulin before and after regimen conversion and changes in hemoglobin A1c, body weight, lipids, and episodes of severe hypoglycemia. Fifty-three patients met inclusion criteria. Average hemoglobin A1c level on U100 insulin regimens was 9.1 ± 1.7%, which decreased to 8.1 ± 1.3% (P<.001) after an average of 20 months (range, 6-52 months) on U500 insulin. The total daily insulin dosage at study end was not significantly greater on U500 (415 ± 166 units/day) than on U100 insulin (391 ± 120 units/day) (P = .34). Body weight did not change significantly (134 ± 29 kg vs 136 ± 30 kg, P = .18). There was a 20-mg/dL decrease in total cholesterol (P = .014). Triglyceride values decreased by 97 mg/dL (P = .005). Eight episodes of severe hypoglycemia ...Continue Reading

References

Nov 14, 2003·Diabetologia·A KubosakiAbner L Notkins
Sep 30, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·J Matthew Neal
Aug 29, 2006·Diabetes Care·Wafic S Wafa, Mukhtar I Khan
Feb 13, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Wendy S LaneJay S Skyler
Mar 12, 2010·Reviews in Endocrine & Metabolic Disorders·Fredrick L Dunn
Mar 17, 2010·Diabetes Research and Clinical Practice·Alexandria M DaileyLisa R Tannock

Citations

Mar 16, 2013·Diabetes, Obesity & Metabolism·P Jones, Iskandar Idris
Mar 1, 2016·Postgraduate Medicine·Adrienne BarnoskyAlaleh Mazhari
May 31, 2014·Journal of Diabetes Science and Technology·Amparo de la PeñaJeffrey A Jackson
Nov 29, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Wendy S LaneRebecca S Lane
Jan 23, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Elizabeth L EbyJeffrey A Jackson
Jan 30, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Purnima Rani Tripathy, M Cecilia Lansang
May 15, 2015·BMJ Open Diabetes Research & Care·Elizabeth L EbyJeffrey A Jackson

Related Concepts

Adult
Elderly (population group)
Body Weight
Diabetes Mellitus, Non-Insulin-Dependent
Females
Hb A1a-2
Homo sapiens
Reactive Hypoglycemia
Hypoglycemic Effect
Novolin

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

© 2021 Meta ULC. All rights reserved