PMID: 7993529Aug 1, 1994Paper

U50488 reduces the severity of tissue damage in a rabbit model of focal cerebral ischemia

Molecular and Chemical Neuropathology
M A WidmayerD S Baskin

Abstract

Many pharmacotherapies for stroke that have been successful in the laboratory have proven to be ineffective in the clinical setting, often because patients do not arrive for treatment until hours after the onset of the ischemic insult. Kappa opioid treatment of cerebral ischemia has been successful in the cat and mouse with treatment delays of up to 6 h. The purpose of the present study was to develop a model of delayed kappa opioid treatment of cerebral ischemia in the rabbit. Fourteen rabbits underwent permanent, unilateral occlusion of the internal carotid, middle cerebral, and anterior cerebral arteries via a transorbital, microsurgical approach. At 6 h postocclusion, animals received a blinded bolus injection and continuous infusion of either saline or the kappa agonist, U50488. Survival was not improved after U50488 treatment. U50488 treatment did, however, reduce areas of severe tissue damage and increase areas of modest tissue damage. This suggests U50488 arrested the progression of damage from noninfarcted to fully infarcted tissue. The present results show beneficial effects of delayed treatment with kappa agonists in a species similar in vasculature to humans, and much less costly than primates or cats.

References

Jul 1, 1975·Stroke; a Journal of Cerebral Circulation·J D Michenfelder, J H Milde
Apr 12, 1991·Brain Research·P C ContrerasB R de Costa
Jan 1, 1990·Epidemiology·K J Rothman
Apr 1, 1989·Pacing and Clinical Electrophysiology : PACE·T Matsui, Y Hosobuchi
May 1, 1989·Stroke; a Journal of Cerebral Circulation·L PerssonY Olsson
Aug 1, 1989·Stroke; a Journal of Cerebral Circulation·A WakayamaW D Heiss
Dec 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K YamamotoT Yanagihara
Feb 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F B MeyerT L Yaksh
Jan 1, 1984·Acta Neuropathologica·T M LiszczakN T Zervas
Jan 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O U ScreminE H Rubinstein
Nov 1, 1980·Stroke; a Journal of Cerebral Circulation·K A Hossmann, F J Schuier
Oct 1, 1994·Stroke; a Journal of Cerebral Circulation·D S BaskinW K Schmidt
Oct 1, 1962·The Journal of Comparative Neurology·D J PROLO, D L STILWELL
Jul 1, 1951·The Journal of Physiology·D A McDONALD, J M POTTER

❮ Previous
Next ❯

Citations

Jan 1, 1995·Peptides·G A OlsonA J Kastin
Jul 2, 2005·Expert Opinion on Investigational Drugs·A Barber, R Gottschlich
Sep 23, 1998·Biochemical Pharmacology·S HuC C Chao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.