Abstract
To explore the prognostic value of UBASH3B in ER+ breast cancer patients and explore potential molecular mechanisms. Datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were re-analyzed to explore the association between UBASH3B and the progression of ER+ breast cancer. Kaplan-Meier plot analysis with a total of 734 ER+ samples and Gene Set Enrichment Analysis with 632 samples were used in the study. High expression of UBASH3B is negatively correlated with distant metastasis free survival (DMFS,P =0.01,P =0.045,P =0.04 in 2 independent datasets and a merged dataset, respectively), disease specific survival (DSS,P =0.028) and disease free survival (DFS,P =0.0052,P =0.011,P =0.016 in 3 independent datasets, respectively) in ER+ breast cancer patients. Subset analysis found that UBASH3B also has prognostic value on both lymph node positive and negative sub-populations with ER+ breast cancer. This study also demonstrates that UBASH3B expression is tightly associated with tamoxifen resistance and TP53 mutation, which explains the association between UBASH3B and poor prognosis of ER+ breast cancer. Further analyses show that the expression of UBASH3B is affected by promoter methylation and copy number loss....Continue Reading
References
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
May 26, 2004·The Journal of Biological Chemistry·Katarzyna KowanetzIvan Dikic
Jun 15, 2004·Cancer Cell·Xiao-Jun MaDennis C Sgroi
Mar 2, 2005·International Journal of Epidemiology·Michelle D AlthuisLouise A Brinton
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lance D MillerJonas Bergh
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Nov 11, 2005·Breast Cancer Research : BCR·Yudi PawitanJonas Bergh
Feb 14, 2007·Oncogene·J A VendrellP A Cohen
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sherene LoiChristos Sotiriou
Aug 17, 2010·Oncogene·H AguilarM A Pujana
Nov 26, 2010·Nucleic Acids Research·Tanya BarrettAlexandra Soboleva
Jun 30, 2011·PloS One·Sanaa Al SalehYunus A Luqmani
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Apr 25, 2013·PloS One·Allan Peter DavisCarolyn J Mattingly
Jun 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shuet Theng LeeQiang Yu
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jun 17, 2015·Cancer Research·Sara I CunhaKristian Pietras